{"doi":"10.1016/j.immuni.2023.02.016","title":"T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity","abstract":"The recent revolution in tissue-resident macrophage biology has resulted largely from murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we analyze immune cells in the pleural cavity. Unlike C57BL/6 mice, naive tissue-resident large-cavity macrophages (LCMs) of BALB/c mice failed to fully implement the tissue-residency program. Following infection with a pleural-dwelling nematode, these pre-existing differences were accentuated with LCM expansion occurring in C57BL/6, but not in BALB/c mice. While infection drove monocyte recruitment in both strains, only in C57BL/6 mice were monocytes able to efficiently integrate into the resident pool. Monocyte-to-macrophage conversion required both T cells and interleukin-4 receptor alpha (IL-4Rα) signaling. The transition to tissue residency altered macrophage function, and GATA6 + tissue-resident macrophages were required for host resistance to nematode infection. Therefore, during tissue nematode infection, T helper 2 (Th2) cells control the differentiation pathway of resident macrophages, which determines infection outcome.","journal":"Immunity","year":2023,"id":318587,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1025935,"name":"James E Parkinson","orcid":"0000-0003-4881-5121","position":1,"is_corresponding":false},{"id":1025936,"name":"Lili Zhang","orcid":"0009-0008-0822-8065","position":2,"is_corresponding":false},{"id":1025937,"name":"Brian H. K. Chan","orcid":"0000-0002-9451-4621","position":3,"is_corresponding":false},{"id":1025938,"name":"Jesuthas Ajendra","orcid":"0000-0002-9256-5396","position":4,"is_corresponding":false},{"id":1025939,"name":"Alistair Chenery","orcid":"0000-0001-8755-461X","position":5,"is_corresponding":false},{"id":1025940,"name":"Anya Morrison","orcid":"0000-0001-6844-1126","position":6,"is_corresponding":false},{"id":232802,"name":"Irem Kaymak","orcid":"0000-0003-0772-512X","position":7,"is_corresponding":false},{"id":258763,"name":"Emma L. Houlder","orcid":"0000-0003-0448-6055","position":8,"is_corresponding":false},{"id":471078,"name":"Syed Murtuza Baker","orcid":"0000-0002-6633-333X","position":9,"is_corresponding":false},{"id":1025941,"name":"Ben Dickie","orcid":"0000-0001-5018-2111","position":10,"is_corresponding":false},{"id":473147,"name":"Louis Boon","orcid":"0000-0002-0937-9171","position":11,"is_corresponding":false},{"id":451586,"name":"Joanne E. Konkel","orcid":"0000-0002-6525-5499","position":12,"is_corresponding":false},{"id":607043,"name":"Matthew R. Hepworth","orcid":"0000-0002-9613-7858","position":13,"is_corresponding":false},{"id":337034,"name":"Andrew S. MacDonald","orcid":"0000-0002-5356-1149","position":14,"is_corresponding":false},{"id":61573,"name":"Gwendalyn J. Randolph","orcid":"0000-0001-9045-1195","position":15,"is_corresponding":false},{"id":1025942,"name":"Dominik Rückerl","orcid":"0000-0002-0206-1451","position":16,"is_corresponding":false},{"id":59356,"name":"Judith E. Allen","orcid":"0000-0002-3829-066X","position":17,"is_corresponding":false},{"id":1025934,"name":"Conor M. Finlay","orcid":"0000-0001-8285-0903","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:07:01.300821Z","pmid":"36948193","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}