{"doi":"10.1016/j.immuni.2019.09.005","title":"Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses","abstract":"Neuroimmune interactions have emerged as critical modulators of allergic inflammation, and type 2 innate lymphoid cells (ILC2s) are an important cell type for mediating these interactions. Here, we show that ILC2s expressed both the neuropeptide calcitonin gene-related peptide (CGRP) and its receptor. CGRP potently inhibited alarmin-driven type 2 cytokine production and proliferation by lung ILC2s both in vitro and in vivo. CGRP induced marked changes in ILC2 expression programs in vivo and in vitro, attenuating alarmin-driven proliferative and effector responses. A distinct subset of ILCs scored highly for a CGRP-specific gene signature after in vivo alarmin stimulation, suggesting CGRP regulated this response. Finally, we observed increased ILC2 proliferation and type 2 cytokine production as well as exaggerated responses to alarmins in mice lacking the CGRP receptor. Together, these data indicate that endogenous CGRP is a critical negative regulator of ILC2 responses in vivo.","journal":"Immunity","year":2019,"id":10443,"datarank":0.8233406589235032,"base_score":5.488937726156687,"endowment":5.488937726156687,"self_citation_contribution":0.8233406589235032,"citation_network_contribution":0.0,"self_endowment_contribution":0.8233406589235032,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":241,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0409,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2019-10-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":14742,"name":"Patrick R. Burkett","orcid":"0000-0003-4472-7124","position":1,"is_corresponding":false},{"id":14743,"name":"Samantha J. Riesenfeld","orcid":"0000-0001-9144-021X","position":2,"is_corresponding":false},{"id":86984,"name":"Se-Jin Kim","orcid":"0000-0002-6704-4644","position":3,"is_corresponding":false},{"id":37423,"name":"Elena Christian","orcid":"0000-0002-5593-0155","position":4,"is_corresponding":false},{"id":4667,"name":"Raja-Elie E. Abdulnour","orcid":"0000-0002-8053-0145","position":5,"is_corresponding":false},{"id":36097,"name":"Pratiksha I. Thakore","orcid":null,"position":6,"is_corresponding":false},{"id":14737,"name":"Alexandra Schnell","orcid":"0000-0003-3442-7750","position":7,"is_corresponding":false},{"id":59684,"name":"Conner D. Lambden","orcid":null,"position":8,"is_corresponding":false},{"id":17248,"name":"Rebecca H. Herbst","orcid":"0000-0002-1004-8919","position":9,"is_corresponding":false},{"id":86985,"name":"Pavana Khan","orcid":"0000-0002-2891-5101","position":10,"is_corresponding":false},{"id":86986,"name":"Kazutake Tsujikawa","orcid":"0000-0003-1870-9790","position":11,"is_corresponding":false},{"id":5342,"name":"Preben Bo Mortensen","orcid":"0000-0002-5230-9865","position":12,"is_corresponding":false},{"id":40859,"name":"Isaac M. Chiu","orcid":"0000-0002-0723-4841","position":13,"is_corresponding":false},{"id":40860,"name":"Bruce D. Levy","orcid":"0000-0001-9515-5731","position":14,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":15,"is_corresponding":false},{"id":6940,"name":"Vijay K. Kuchroo","orcid":"0000-0001-7177-2110","position":16,"is_corresponding":false},{"id":14741,"name":"Antonia Wallrapp","orcid":"0000-0002-3176-1553","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}