{"doi":"10.1016/j.immuni.2008.10.013","title":"Autoreactive B Cell Receptors Mimic Autonomous Pre-B Cell Receptor Signaling and Induce Proliferation of Early B Cells","abstract":null,"journal":"Immunity","year":2008,"id":610675,"datarank":0.7117398192544876,"base_score":4.74493212836325,"endowment":4.74493212836325,"self_citation_contribution":0.7117398192544876,"citation_network_contribution":0.0,"self_endowment_contribution":0.7117398192544876,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1570157,"name":"Eva Hug","orcid":null,"position":1,"is_corresponding":false},{"id":1570159,"name":"Cathrin Eschbach","orcid":null,"position":2,"is_corresponding":false},{"id":1570161,"name":"Sonja Meixlsperger","orcid":null,"position":3,"is_corresponding":false},{"id":362262,"name":"Elias Hobeika","orcid":"0000-0002-5068-061X","position":4,"is_corresponding":false},{"id":1570162,"name":"Juliane Kofer","orcid":null,"position":5,"is_corresponding":false},{"id":486503,"name":"Hedda Wardemann","orcid":"0000-0003-3921-5933","position":6,"is_corresponding":false},{"id":362264,"name":"Hassan Jumaa","orcid":"0000-0003-3383-141X","position":7,"is_corresponding":false},{"id":465637,"name":"Fabian Köhler","orcid":"0000-0002-9437-5967","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Autoreactive B Cell Receptors Mimic Autonomous Pre-B Cell Receptor Signaling and Induce Proliferation of Early B Cells","abstract":"The majority of early immature B cells express autoreactive B cell receptors (BCRs) that are, according to the current view, negatively selected to avoid the production of self-reactive antibodies. Here, we show that polyreactive BCRs, which recognize multiple self-antigens, induced autonomous signaling and selective expansion of B cell precursors in a manner comparable to the pre-BCR. We found that the pre-BCR was capable of recognizing multiple self-antigens and that a signaling-deficient pre-BCR lacking the non-Ig region of the surrogate-light-chain component lambda5 was rescued by the complementarity-determining region 3 derived from heavy chains of polyreactive receptors. Importantly, bone marrow B cells from mice carrying Ig transgenes for an autoreactive BCR showed increased cell-cycle activity, which could not be detected in cells lacking the transgenic BCR. Together, the pre-BCR has evolved to ensure self-recognition because autoreactivity is required for positive selection of B cell precursors.","is_dataset_classified":null,"base_score":4.74493212836325,"endowment":4.74493212836325,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19084434","pmcid":null,"openalex_id":"https://openalex.org/W2050651394","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"SFB620","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"SFB746","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Boehringer Ingelheim Fonds","grant_id":"","title":null}],"total_grants":4,"fwci":2.3285,"citation_percentile":0.88440624,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":5},{"year":2014,"count":14},{"year":2015,"count":10},{"year":2016,"count":10},{"year":2017,"count":2},{"year":2018,"count":8},{"year":2019,"count":3},{"year":2020,"count":10},{"year":2021,"count":6},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":5},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S1074761308005050/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1074761308005050/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1074761308005050?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1074761308005050?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.immuni.2008.10.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19084434","host_type":"repository"},{"url":"http://edoc.mpg.de/397946","host_type":"repository"},{"url":"http://hdl.handle.net/11858/00-001M-0000-002B-8FEE-9","host_type":"repository"},{"url":"http://hdl.handle.net/11858/00-001M-0000-000E-C14D-0","host_type":"repository"},{"url":"https://hdl.handle.net/11858/00-001M-0000-002B-8FEE-9","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.immuni.2008.10.013","host_type":""},{"url":"https://dx.doi.org/10.1016/j.immuni.2008.10.013","host_type":""},{"url":"https://hdl.handle.net/11858/00-001M-0000-000E-C14D-0","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Immunotherapy and Immune Responses","CAR-T cell therapy research","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Adaptor Proteins, Signal Transducing","Animals","Autoantigens","B-Lymphocytes","Cell Line","DNA-Binding Proteins","Mice","Mice, Transgenic","Molecular Mimicry","Pre-B Cell Receptors","Receptors, Antigen, B-Cell","Recombinant Fusion Proteins","Signal Transduction"],"mesh_terms":["Animals","Autoantigens","B-Lymphocytes","Cell Line","DNA-Binding Proteins","Mice, Transgenic","Receptors, Antigen, B-Cell","Recombinant Fusion Proteins","Signal Transduction","Molecular Mimicry","Adaptor Proteins, Signal Transducing","Mice","Pre-B Cell Receptors"],"keywords":["breakpoint cluster region","Biology","B-cell receptor","B cell","Receptor","Cell biology","Antigen","Transgene","Signal transduction","Immunology","Antibody","Molecular biology","Genetics","Gene","B-Lymphocytes","Recombinant Fusion Proteins","Molecular Mimicry","Receptors, Antigen, B-Cell","Mice, Transgenic","Autoantigens","Cell Line","DNA-Binding Proteins","Mice","Infectious Diseases","Pre-B Cell Receptors","Immunology and Allergy","Animals","MOLIMMUNO","Adaptor Proteins, Signal Transducing"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T10:27:27.198871Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}