{"doi":"10.1016/j.imbio.2019.11.006","title":"Oxidative stress and immune complexes: Pathogenic mechanisms in pristane induced murine model of lupus","abstract":null,"journal":"Immunobiology","year":2020,"id":686773,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1794203,"name":"Archana Bhatnagar","orcid":null,"position":1,"is_corresponding":false},{"id":1794200,"name":"Naveet Pannu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Oxidative stress and immune complexes: Pathogenic mechanisms in pristane induced murine model of lupus","abstract":"Systemic lupus erythematosus is a systemic autoimmune inflammatory disease with a broad spectrum of clinical presentations. Mouse models play an indispensible role in understanding the disease pathology and for developing new therapeutics. This study investigated the effect of pristane administration on female BALB/c mice. The various manifestations of lupus replicated in this mouse model were analysed and their relevance to human disease was assessed. Pristane injection replicates the two prime manifestations of lupus i.e. oxidative stress and inflammation. An increase in oxidative stress was determined by the decreasing anti-oxidants, increasing ROS and lipid peroxidation. Inflammatory cytokines (IL-6 and TNF-α) also increased in the plasma. The deteriorating organ functions after pristane administration were evident histopathologically. An increase in inflammatory cells, necrosis, oil vacuoles and pigment cells were marked in kidney, liver, lungs and spleen, whereas skin did not manifest any alteration. Liver function (bilirubin, SGPT) and kidney function (creatinine and proteinuria) tests were also altered. Pristane injection caused the generation of anti-nuclear antibodies, which were apparent from the different immunofluorescence patterns observed. Immune deposits were evident in all the vital organs stating the similarity this model holds with lupus patients. Replicating various manifestations of human lupus disorder, pristane induced mouse model of lupus serves as an appropriate model to study lupus complications and in the development of novel therapeutics for disease management.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31780314","pmcid":null,"openalex_id":"https://openalex.org/W2990381245","authors":[],"funders":[{"funder_name":"University Grant Commission- Basic Scientific Research","grant_id":"F4-1/2006(BSR)/7-209/2009(BSR)","title":null},{"funder_name":"epartment of Science & Technology - Promotion of University Research and Scientific Excellence","grant_id":"","title":null},{"funder_name":"niversity Grants Commission- Special Assistance Programme","grant_id":"","title":null}],"total_grants":3,"fwci":0.6616,"citation_percentile":0.70684498,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":7},{"year":2025,"count":2},{"year":2026,"count":5}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0171298519302025?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0171298519302025?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.imbio.2019.11.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31780314","host_type":"repository"}],"fields_of_study":["Systemic Lupus Erythematosus Research","Atherosclerosis and Cardiovascular Diseases","Cytokine Signaling Pathways and Interactions","Animals","Antibodies, Antinuclear","Antigen-Antibody Complex","Cytokines","Disease Models, Animal","Feasibility Studies","Female","Humans","Inflammation","Inflammation Mediators","Lipid Peroxidation","Lupus Erythematosus, Systemic","Lupus Nephritis","Mice","Mice, Inbred BALB C","Oxidative Stress","Reactive Oxygen Species","Terpenes"],"mesh_terms":["Animals","Antigen-Antibody Complex","Antibodies, Antinuclear","Disease Models, Animal","Feasibility Studies","Female","Humans","Inflammation","Lupus Erythematosus, Systemic","Lupus Nephritis","Mice, Inbred BALB C","Terpenes","Lipid Peroxidation","Cytokines","Reactive Oxygen Species","Oxidative Stress","Inflammation Mediators","Mice"],"keywords":["Systemic lupus erythematosus","Pristane","Inflammation","Immune system","Immunology","Oxidative stress","Lupus nephritis","Medicine","Kidney","Autoimmune disease","Antibody","Endocrinology","Internal medicine","Chemistry","Disease","Liver function","Immune complexes","Kidney Function","Anti-nuclear Antibodies","Histopathological Alterations"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T20:26:14.213145Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}