{"doi":"10.1016/j.ijrobp.2022.04.047","title":"Functional Lung Avoidance for Individualized Radiation Therapy: Results of a Double-Masked, Randomized Controlled Trial","abstract":null,"journal":"International Journal of Radiation Oncology*Biology*Physics","year":2022,"id":683161,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1784645,"name":"Dante P.I. Capaldi","orcid":null,"position":1,"is_corresponding":false},{"id":1029580,"name":"Khadija Sheikh","orcid":"0000-0002-1168-1783","position":2,"is_corresponding":false},{"id":382758,"name":"David A. Palma","orcid":"0000-0002-9542-0627","position":3,"is_corresponding":false},{"id":299179,"name":"Andrew Warner","orcid":"0000-0001-6023-1423","position":4,"is_corresponding":false},{"id":1466371,"name":"A. Rashid Dar","orcid":null,"position":5,"is_corresponding":false},{"id":308716,"name":"Edward Yu","orcid":"0000-0001-5912-1227","position":6,"is_corresponding":false},{"id":1784646,"name":"George B. Rodrigues","orcid":null,"position":7,"is_corresponding":false},{"id":252418,"name":"Alexander V. Louie","orcid":"0000-0002-3569-9099","position":8,"is_corresponding":false},{"id":1784647,"name":"Mark Landis","orcid":null,"position":9,"is_corresponding":false},{"id":1784648,"name":"Michael Sanatani","orcid":null,"position":10,"is_corresponding":false},{"id":1784649,"name":"Mark D. Vincent","orcid":null,"position":11,"is_corresponding":false},{"id":1784650,"name":"Jawaid Younus","orcid":null,"position":12,"is_corresponding":false},{"id":384114,"name":"Sara Kuruvilla","orcid":null,"position":13,"is_corresponding":false},{"id":1784651,"name":"Jeff Z. Chen","orcid":null,"position":14,"is_corresponding":false},{"id":1784652,"name":"Abigail Erickson","orcid":null,"position":15,"is_corresponding":false},{"id":1784653,"name":"Stewart Gaede","orcid":null,"position":16,"is_corresponding":false},{"id":1784654,"name":"Grace Parraga","orcid":null,"position":17,"is_corresponding":false},{"id":1227427,"name":"Douglas A. Hoover","orcid":"0000-0003-0923-6354","position":18,"is_corresponding":false},{"id":1784644,"name":"Brian P. Yaremko","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Functional Lung Avoidance for Individualized Radiation Therapy: Results of a Double-Masked, Randomized Controlled Trial","abstract":"<h4>Purpose</h4>To determine whether functional lung avoidance based on <sup>3</sup>He magnetic resonance imaging (MRI) improves quality of life (QOL) for patients undergoing concurrent chemoradiotherapy (CCRT) for advanced non-small cell lung cancer.<h4>Methods and materials</h4>Patients with stage III non-small cell lung cancer (or oligometastatic disease treated with curative intent) undergoing CCRT with at least a 10 pack-year smoking history were eligible. Patients underwent pretreatment <sup>3</sup>He MRI to measure lung ventilation and had 2 radiation therapy (RT) plans created before randomization: a standard plan, which did not make use of the <sup>3</sup>He MRI, and an avoidance plan, preferentially sparing well-ventilated lung. All participants were masked to assignment except the physicist responsible for exporting the selected plan. The primary end point was patient-reported QOL measured at 3-months post-RT by the FACT-L lung cancer subscale (LCS); secondary end points included other QOL metrics, toxicity, and survival outcomes. Target accrual was 64.<h4>Results</h4>Twenty-seven patients were randomized before the trial was closed due to slower-than-expected accrual, with 11 randomized to the standard arm and 16 to the avoidance arm. Baseline patient characteristics were well-balanced. At 3 months post-RT, the mean ± SD LCS scores were 17.4 ± 2.8 versus 17.3 ± 6.1 for the standard and avoidance arms, respectively (P = .485). A clinically meaningful, prespecified decline of ≥3 points in the LCS score was observed in 50% (4/8) in the standard arm and 33% (4/12) in the avoidance arm (P = .648). Two patients in each arm developed grade ≥2 radiation pneumonitis, with no grade ≥4 toxicities.<h4>Conclusions</h4>Although this trial did not reach full accrual, QOL scores were very similar between arms. Due to the scarcity of <sup>3</sup>He MRI, other, more commonly available methods to measure functional lung, such as 4-dimensional computed tomography ventilation mapping, may be considered in the assessment of functional lung avoidance RT, and a larger, multicenter approach would be needed to accrue sufficient patients to test such approaches.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35550405","pmcid":null,"openalex_id":"https://openalex.org/W4229372791","authors":[],"funders":[],"total_grants":0,"fwci":2.4743,"citation_percentile":0.89143804,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":5},{"year":2024,"count":9},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0360301622004084?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0360301622004084?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ijrobp.2022.04.047","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35550405","host_type":"repository"}],"fields_of_study":["Effects of Radiation Exposure","Lung Cancer Diagnosis and Treatment","Advanced Radiotherapy Techniques","Carcinoma, Non-Small-Cell Lung","Chemoradiotherapy","Humans","Lung","Lung Neoplasms","Male","Quality of Life"],"mesh_terms":["Carcinoma, Non-Small-Cell Lung","Humans","Lung","Lung Neoplasms","Male","Quality of Life","Chemoradiotherapy"],"keywords":["Medicine","Randomized controlled trial","Lung cancer","Quality of life (healthcare)","Clinical endpoint","Randomization","Radiation therapy","Chemoradiotherapy","Magnetic resonance imaging","Internal medicine","Radiology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T22:43:28.428502Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}