{"doi":"10.1016/j.ijregi.2022.04.006","title":"Covishield vaccine induces robust immune responses in Bangladeshi adults","abstract":"To evaluate severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific antibody responses after Covishield vaccination for 6 months after vaccination. SARS-CoV-2-specific antibody responses were assessed by enzyme-linked immunosorbent assay of the recombinant receptor-binding domain of SARS-CoV-2 in 381 adults given the Covishield vaccine at baseline (n=119), 1 month (n=126) and 2 months (n=75) after the first dose, 1 month after the second dose (n=161), and monthly for 3 additional months. Over 51% of participants were seropositive at baseline (before vaccination with Covishield), and almost all participants (159/161) became seropositive 1 month after the second dose. Antibody levels peaked 1 month after receipt of the second dose of vaccine, and decreased by 4 months after the first dose; the lowest responses were found 6 months after the first dose, although antibody responses and responder frequencies remained significantly higher compared with baseline (P<0.0001). Compared with younger participants, older participants had lower antibody responses 6 months after the first dose of vaccine (P<0.05). Participants who had previous SARS-CoV-2 infection showed robust higher antibody responses after vaccination. These findings help to elucidate the longevity of vaccine-specific antibody responses following vaccination with Covishield, and provide information relevant to the planning of booster doses after the initial two doses of vaccine.","journal":"IJID Regions","year":2022,"id":273893,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576810,"name":"Marjahan Akhtar","orcid":"0000-0001-8316-9191","position":1,"is_corresponding":false},{"id":354554,"name":"Fatema Khaton","orcid":null,"position":2,"is_corresponding":false},{"id":930864,"name":"Sadia Rahman","orcid":"0000-0002-7983-087X","position":3,"is_corresponding":false},{"id":352717,"name":"Jannatul Ferdous","orcid":"0000-0003-2390-9404","position":4,"is_corresponding":false},{"id":930868,"name":"A. S. M. Alamgir","orcid":"0000-0002-1240-6089","position":5,"is_corresponding":false},{"id":898624,"name":"Mahbubur Rahman","orcid":"0000-0001-8577-8281","position":6,"is_corresponding":false},{"id":941860,"name":"Zannat Kawser","orcid":"0000-0001-7628-137X","position":7,"is_corresponding":false},{"id":942458,"name":"Imrul Hasan","orcid":null,"position":8,"is_corresponding":false},{"id":109065,"name":"Stephen B. Calderwood","orcid":"0000-0002-2083-7153","position":9,"is_corresponding":false},{"id":109068,"name":"Jason B. Harris","orcid":"0000-0003-3642-5126","position":10,"is_corresponding":false},{"id":108258,"name":"Richelle C. Charles","orcid":"0000-0002-8881-1849","position":11,"is_corresponding":false},{"id":62201,"name":"Regina C. LaRocque","orcid":"0000-0003-4558-0339","position":12,"is_corresponding":false},{"id":108468,"name":"Edward T. Ryan","orcid":"0009-0005-0169-394X","position":13,"is_corresponding":false},{"id":516294,"name":"Sayera Banu","orcid":"0000-0002-5121-1962","position":14,"is_corresponding":false},{"id":422014,"name":"Tahmina Shirin","orcid":"0000-0002-5061-3783","position":15,"is_corresponding":false},{"id":62115,"name":"Firdausi Qadri","orcid":"0000-0002-8928-9888","position":16,"is_corresponding":false},{"id":352712,"name":"Taufiqur Rahman Bhuiyan","orcid":"0000-0003-3755-4763","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:28:07.776043Z","pmid":"35720155","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}