{"doi":"10.1016/j.ijpam.2023.02.001","title":"WITHDRAWN: The ethics of “net-risk” pediatric research:Views of IRB members and the US public","abstract":"US regulations permit institutional review boards (IRBs) to approve “net-risk” pediatric research only when the risks are minimal or a minor increase over minimal. This study assessed whether IRB members agree with these risk limits and compared their views with the views of US adults. An online survey of IRB members was conducted. Participants were randomized to 1 of 4 studies, which pose increasing risks, and asked to consider the three versions that offer increasing potential social value. A total of 107 individuals met the inclusion criteria. Overall, 98% of the respondents indicated that net-risk pediatric research can be appropriate. Of the 77 who passed the comprehension test, more than 90% indicated a research-based blood draw can be appropriate, a clear majority endorsed a research-based bone marrow biopsy, and a majority supported somewhat greater risks when the study has high potential social value. The percentage who indicated that the specified research procedure was appropriate increased as the potential social value increased. Compared with US adults, IRB members were more likely to think net-risk pediatric research is appropriate when the risks are low, but less likely when the risks are higher. The vast majority of IRB members consider it appropriate to expose children to some research risks for the benefit of others. Moreover, a majority think greater risks can be appropriate when the research has greater potential social value. These findings, together with similar findings from US adults, suggest that current regulations for pediatric research may be overly restrictive.","journal":"International Journal of Pediatrics and Adolescent Medicine","year":2023,"id":403204,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.964,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":402998,"name":"Will Schupmann","orcid":"0000-0002-5937-8118","position":1,"is_corresponding":false},{"id":413699,"name":"Xiaobai Li","orcid":"0000-0001-9615-3543","position":2,"is_corresponding":false},{"id":330802,"name":"David Wendler","orcid":"0000-0002-9359-4439","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:20:32.588152Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}