{"doi":"10.1016/j.ijid.2023.04.396","title":"Real-world evaluation of bebtelovimab effectiveness during the period of COVID-19 Omicron variants, including BA.4/BA.5","abstract":"OBJECTIVES: Bebtelovimab is an anti-SARS-CoV-2 monoclonal antibody active against Omicron lineage variants authorized to treat high-risk outpatients with COVID-19. We sought to determine the real-world effectiveness of bebtelovimab during the Omicron phases BA.2/BA2.12.1/BA4/BA5. METHODS: We conducted a retrospective cohort study of adults with SARS-CoV-2 infection between April 6 and October 11, 2022, using health records linked to vaccine and mortality data. We used propensity scores to match of bebtelovimab-treated with untreated outpatients. The primary outcome was 28-day all-cause hospitalization. The secondary outcomes were 28-day COVID-19-related hospitalization, 28-day all-cause mortality, 28-day emergency department visits, maximum respiratory support level, intensive care unit admission, and in-hospital mortality among hospitalized patients. We used logistic regression to determine bebtelovimab treatment effectiveness. RESULTS: Among 22,720 patients with SARS-COV-2 infection, 3739 bebtelovimab-treated patients were matched to 5423 untreated patients. Compared with no treatment, bebtelovimab was associated with lower odds of 28-day all-cause hospitalization (1.3% vs 2.1%, adjusted odds ratio: 0.53; 95% confidence interval: 0.37-0.74, P <0.001), as well as COVID-19-related hospitalization (1.0% vs 2.0%, adjusted odds ratio: 0.44 [95% confidence interval: 0.30-0.64], P <0.001). Bebtelovimab appeared to be more beneficial in lowering the odds of hospitalization among patients with two or more comorbidities (interaction P = 0.03). CONCLUSION: During the Omicron BA.2/BA.2.12.1/BA.4/BA.5 variant phase, bebtelovimab was associated with lower hospitalization.","journal":"International Journal of Infectious Diseases","year":2023,"id":358388,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9297,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":694636,"name":"Victoria Kennerley","orcid":null,"position":1,"is_corresponding":false},{"id":862342,"name":"Laurel Beaty","orcid":"0000-0001-8021-7872","position":2,"is_corresponding":false},{"id":49886,"name":"Tellen D. Bennett","orcid":"0000-0003-1483-4236","position":3,"is_corresponding":false},{"id":519059,"name":"Nichole E. Carlson","orcid":"0000-0003-0679-6663","position":4,"is_corresponding":false},{"id":11318,"name":"David A Mayer","orcid":"0000-0002-6056-9771","position":5,"is_corresponding":false},{"id":975302,"name":"Jennifer L. Peers","orcid":null,"position":6,"is_corresponding":false},{"id":558539,"name":"Seth Russell","orcid":"0000-0002-2436-1367","position":7,"is_corresponding":false},{"id":562767,"name":"Matthew K. Wynia","orcid":"0000-0003-3307-069X","position":8,"is_corresponding":false},{"id":604590,"name":"Neil R. Aggarwal","orcid":"0000-0002-0922-8824","position":9,"is_corresponding":false},{"id":105999,"name":"Adit A. Ginde","orcid":"0000-0003-2325-206X","position":10,"is_corresponding":false},{"id":705144,"name":"Kyle C. Molina","orcid":"0000-0002-6764-5984","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:13:43.629667Z","pmid":"37072054","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}