{"doi":"10.1016/j.ijid.2022.07.035","title":"Cytomegalovirus viremia as a risk factor for mortality in HIV-associated cryptococcal and tuberculous meningitis","abstract":"OBJECTIVES: CMV viremia is associated with increased mortality in persons with HIV. We previously demonstrated that CMV viremia was a risk factor for 10-week mortality in antiretroviral therapy (ART)-naïve persons with cryptococcal meningitis. We investigated whether similar observations existed over a broader cohort of patients with HIV-associated meningitis at 18 weeks. METHODS: We prospectively enrolled Ugandans with cryptococcal or TB meningitis into clinical trials in 2015-2019. We quantified CMV DNA concentrations from stored baseline plasma or serum samples from 340 participants. We compared 18-week survival between those with and without CMV viremia. RESULTS: IU/ml increase; 95% CI 1.09-1.35; P <0.001) were positively associated with all-cause mortality through 18 weeks. CONCLUSION: CMV viremia at baseline was associated with a higher risk of death at 18 weeks among persons with HIV-associated cryptococcal or TB meningitis, and the risk increased as the CMV viral load increased. Further investigation is warranted to determine whether CMV is a modifiable risk contributing to deaths in HIV-associated meningitis or is a biomarker of immune dysfunction.","journal":"International Journal of Infectious Diseases","year":2022,"id":258862,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.961,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":269372,"name":"Katherine Huppler Hullsiek","orcid":null,"position":1,"is_corresponding":false},{"id":418473,"name":"Fiona V Cresswell","orcid":"0000-0002-5070-532X","position":2,"is_corresponding":false},{"id":910906,"name":"Kiiza Kandole Tadeo","orcid":null,"position":3,"is_corresponding":false},{"id":644486,"name":"Michael Okirwoth","orcid":"0000-0002-8651-7478","position":4,"is_corresponding":false},{"id":910907,"name":"Mark Blackstad","orcid":null,"position":5,"is_corresponding":false},{"id":910480,"name":"Nelmary Hernandez-Alvarado","orcid":"0000-0001-5928-8983","position":6,"is_corresponding":false},{"id":910481,"name":"Claudia Fernández-Alarcón","orcid":"0000-0003-2210-7792","position":7,"is_corresponding":false},{"id":910482,"name":"Stewart Walukaga","orcid":"0009-0002-5361-4076","position":8,"is_corresponding":false},{"id":447828,"name":"Emily Martyn","orcid":"0000-0003-4981-9298","position":9,"is_corresponding":false},{"id":735381,"name":"Jayne Ellis","orcid":"0000-0002-7009-9144","position":10,"is_corresponding":false},{"id":452980,"name":"Kenneth Ssebambulidde","orcid":"0000-0002-8125-0698","position":11,"is_corresponding":false},{"id":452981,"name":"Lillian Tugume","orcid":"0000-0002-1293-1545","position":12,"is_corresponding":false},{"id":292463,"name":"Edwin Nuwagira","orcid":"0000-0001-7526-9504","position":13,"is_corresponding":false},{"id":445888,"name":"Joshua Rhein","orcid":"0000-0002-0480-9646","position":14,"is_corresponding":false},{"id":397657,"name":"David B. Meya","orcid":"0000-0002-8854-0321","position":15,"is_corresponding":false},{"id":267658,"name":"David R. Boulware","orcid":"0000-0002-4715-0060","position":16,"is_corresponding":false},{"id":326174,"name":"Mark R. Schleiss","orcid":"0000-0002-2108-9433","position":17,"is_corresponding":false},{"id":267647,"name":"Caleb P Skipper","orcid":"0000-0002-0000-8876","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T00:25:43.037820Z","pmid":"35843498","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}