{"doi":"10.1016/j.ijid.2022.02.038","title":"Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness","abstract":"OBJECTIVES: To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses. METHODS: We conducted 2 cohort studies on: (1) 972 schoolchildren from November 2009-March 2010 to evaluate pandemic policies and (2) 935 schoolchildren from November 2011-March 2012 to verify factors in antibody waning. Anti-influenza H1N1pdm09 hemagglutination inhibition antibodies (HI-Ab) were measured from serum samples collected before vaccination, and at 1 and 4 months after vaccination. Factors affecting HI-Ab responses were investigated through logistic regression and generalized estimating equation. RESULTS: Seroprevalence of H1N1pdm09 before vaccination was significantly higher among schoolchildren who experienced class suspensions than those who did not (59.6% vs 47.5%, p<0.05). Participating in after-school activities (adjusted odds ratio [aOR]=2.47, p=0.047) and having ≥3 hours per week of exercise (aOR=2.86, p=0.019) were significantly correlated with H1N1pdm09 infection. Two doses of the H1N1pdm09 vaccine demonstrated significantly better antibody persistence than 1 dose (HI-Ab geometric mean titer: 132.5 vs 88.6, p=0.047). Vaccine effectiveness after controlling for preexisting immunity was 86% (32%-97%). Exercise ≥3 hours per week and preexisting immunity were significantly associated with antibody waning/maintenance. CONCLUSIONS: This study is the first to show that exercise and preexisting immunity may affect antibody waning. Further investigation is needed to identify immune correlates of protection.","journal":"International Journal of Infectious Diseases","year":2022,"id":295015,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":980697,"name":"Wei Liu","orcid":"0000-0003-2829-4226","position":1,"is_corresponding":false},{"id":262574,"name":"Zheng-Rong Tiger Li","orcid":"0000-0003-0524-279X","position":2,"is_corresponding":false},{"id":981061,"name":"Ta‐Chien Chan","orcid":null,"position":3,"is_corresponding":false},{"id":980698,"name":"Chia‐Chi Ku","orcid":"0000-0002-5740-1505","position":4,"is_corresponding":false},{"id":981062,"name":"Yu-Hui Lien","orcid":null,"position":5,"is_corresponding":false},{"id":981063,"name":"Yea-Huei Shen","orcid":null,"position":6,"is_corresponding":false},{"id":980699,"name":"Juine-Ruey Chen","orcid":"0000-0002-4751-1217","position":7,"is_corresponding":false},{"id":981064,"name":"Muh‐Yong Yen","orcid":null,"position":8,"is_corresponding":false},{"id":623190,"name":"Yu‐Kang Tu","orcid":"0000-0002-2461-474X","position":9,"is_corresponding":false},{"id":980700,"name":"Wan‐Yu Lin","orcid":"0000-0002-3385-4702","position":10,"is_corresponding":false},{"id":535460,"name":"Richard W. Compans","orcid":"0000-0003-2360-335X","position":11,"is_corresponding":false},{"id":980701,"name":"Ping‐Ing Lee","orcid":"0000-0002-7299-2825","position":12,"is_corresponding":false},{"id":980702,"name":"Chwan‐Chuen King","orcid":"0000-0002-6078-2601","position":13,"is_corresponding":false},{"id":981060,"name":"Pui-I Ho","orcid":null,"position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T00:31:05.260069Z","pmid":"35235824","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}