{"doi":"10.1016/j.ijid.2022.02.005","title":"Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus","abstract":"OBJECTIVES: To estimate the prevalence of cytomegalovirus (CMV) infections among newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda. DESIGN AND METHODS: Three populations-newborn-mother pairs, neonates with sepsis, and infants (≤3 months) with nonpostinfectious (NPIH) or postinfectious (PIH) hydrocephalus-were evaluated for CMV infection at 3 medical centers in Uganda. Quantitative PCR (qPCR) was used to characterize the prevalence of CMV. RESULTS: The overall CMV prevalence in 2498 samples across all groups was 9%. In newborn-mother pairs, there was a 3% prevalence of cord blood CMV positivity and 33% prevalence of maternal vaginal shedding. In neonates with clinical sepsis, there was a 2% CMV prevalence. Maternal HIV seropositivity (adjusted odds ratio [aOR] 25.20; 95% confidence interval [CI] 4.43-134.26; p = 0.0001), residence in eastern Uganda (aOR 11.06; 95% CI 2.30-76.18; p = 0.003), maternal age <25 years (aOR 4.54; 95% CI 1.40-19.29; p = 0.02), and increasing neonatal age (aOR 1.08 for each day older; 95% CI 1.00-1.16; p = 0.05), were associated risk factors for CMV in neonates with clinical sepsis. We found a 2-fold higher maternal vaginal shedding in eastern (45%) vs western (22%) Uganda during parturition (n = 22/49 vs 11/50, the Fisher exact test; p = 0.02). In infants with PIH, the prevalence in blood was 24% and in infants with NPIH, it was 20%. CMV was present in the cerebrospinal fluid (CSF) of 13% of infants with PIH compared with 0.5% of infants with NPIH (n = 26/205 vs 1/194, p < 0.0001). CONCLUSIONS: Our findings highlight that congenital and postnatal CMV prevalence is substantial in this African setting, and the long-term consequences are uncharacterized.","journal":"International Journal of Infectious Diseases","year":2022,"id":284621,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9188,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348443,"name":"Paddy Ssentongo","orcid":"0000-0003-1565-5731","position":1,"is_corresponding":false},{"id":243045,"name":"Lisa M. Bebell","orcid":"0000-0003-0077-6522","position":2,"is_corresponding":false},{"id":348450,"name":"Kathy Burgoine","orcid":"0000-0001-7975-745X","position":3,"is_corresponding":false},{"id":348449,"name":"Joel Bazira","orcid":"0000-0001-7600-7514","position":4,"is_corresponding":false},{"id":274640,"name":"Claudio Fronterrè","orcid":"0000-0001-6723-9727","position":5,"is_corresponding":false},{"id":348460,"name":"Elias Kumbakumba","orcid":"0000-0001-7206-0609","position":6,"is_corresponding":false},{"id":958044,"name":"Ronald Mulondo","orcid":null,"position":7,"is_corresponding":false},{"id":348444,"name":"Edith Mbabazi-Kabachelor","orcid":"0000-0001-7912-7116","position":8,"is_corresponding":false},{"id":251035,"name":"Sarah U. Morton","orcid":"0000-0002-7816-2646","position":9,"is_corresponding":false},{"id":484676,"name":"Joseph Ngonzi","orcid":"0000-0001-5253-9516","position":10,"is_corresponding":false},{"id":962379,"name":"Moses Ochora","orcid":"0000-0002-9609-6021","position":11,"is_corresponding":false},{"id":348463,"name":"Peter Olupot‐Olupot","orcid":"0000-0002-5757-609X","position":12,"is_corresponding":false},{"id":349623,"name":"John Mugamba","orcid":null,"position":13,"is_corresponding":false},{"id":349625,"name":"Justin Onen","orcid":null,"position":14,"is_corresponding":false},{"id":243040,"name":"Drucilla J. Roberts","orcid":"0000-0002-9104-6674","position":15,"is_corresponding":false},{"id":348465,"name":"Kathryn Sheldon","orcid":"0000-0002-9093-4645","position":16,"is_corresponding":false},{"id":348442,"name":"Shamim A. Sinnar","orcid":"0000-0002-6625-181X","position":17,"is_corresponding":false},{"id":881125,"name":"Jasmine Smith","orcid":"0000-0002-4636-0138","position":18,"is_corresponding":false},{"id":349628,"name":"Peter Ssenyonga","orcid":null,"position":19,"is_corresponding":false},{"id":348447,"name":"Julius Kiwanuka","orcid":"0000-0001-9442-1719","position":20,"is_corresponding":false},{"id":106253,"name":"Joseph N. Paulson","orcid":"0000-0001-8221-7139","position":21,"is_corresponding":false},{"id":586523,"name":"Frederick A. Meier","orcid":null,"position":22,"is_corresponding":false},{"id":348452,"name":"Jessica E. Ericson","orcid":"0000-0002-8765-2065","position":23,"is_corresponding":false},{"id":249238,"name":"James R. Broach","orcid":"0000-0003-1197-0312","position":24,"is_corresponding":false},{"id":240755,"name":"Steven J. Schiff","orcid":"0000-0003-2623-3614","position":25,"is_corresponding":false},{"id":348440,"name":"Christine Hehnly","orcid":"0000-0003-3739-0690","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T00:29:36.828109Z","pmid":"35150915","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}