{"doi":"10.1016/j.ijid.2020.02.014","title":"A unique immune signature of serum cytokine and chemokine dynamics in patients with Zika virus infection from a tropical region in Southern Mexico","abstract":"OBJECTIVES: To describe the kinetics of circulating cytokines and chemokines in humans with ZIKAV infection. METHODS: Serum levels of different immune mediators in patients with ZIKAV infection were measured at distinct stages of the disease, as well as in culture supernatants from human monocytes infected with a clinical ZIKAV isolate. We also looked for clinical features associated with specific immune signatures among symptomatic patients. RESULTS: We evaluated 23 ZIKAV-infected patients. Their mean age was 32 ± 8.3 years and 65% were female. ZIKAV patients showed elevated IL-9, IL-17A, and CXCL10 levels at acute stages of the disease. At day 28, levels of CCL4 and CCL5 were increased, whereas IL-1RA, CXCL8 and CCL2 were decreased. At baseline, IL-7 was increased among patients with headache, whereas CCL2, and CCL3 were decreased in patients with bleeding and rash, respectively. Our clinical ZIKAV isolate induced a broad immune response in monocytes that did not resemble the signature observed in ZIKAV patients. CONCLUSIONS: We showed a unique immune signature in our cohort of ZIKAV-infected patients. Our study may provide valuable evidence helpful to identify immune correlates of protection against ZIKAV.","journal":"International Journal of Infectious Diseases","year":2020,"id":79255,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246481,"name":"José Alberto Choreño-Parra","orcid":"0000-0002-4591-5285","position":1,"is_corresponding":false},{"id":259056,"name":"Luis Jiménez-Álvarez","orcid":"0000-0002-5326-2720","position":2,"is_corresponding":false},{"id":259055,"name":"Alfredo Cruz‐Lagunas","orcid":"0000-0001-5487-5919","position":3,"is_corresponding":false},{"id":411807,"name":"José Eduardo Márquez-García","orcid":"0000-0003-2172-0114","position":4,"is_corresponding":false},{"id":412818,"name":"Gustavo Ramírez-Martínez","orcid":null,"position":5,"is_corresponding":false},{"id":412819,"name":"Aminadab Goodina","orcid":null,"position":6,"is_corresponding":false},{"id":412820,"name":"Erika Mariana Hernández-Montiel","orcid":null,"position":7,"is_corresponding":false},{"id":246484,"name":"Luis Alejandro Fernández-López","orcid":"0000-0002-8680-1751","position":8,"is_corresponding":false},{"id":412821,"name":"María Fernanda Cabrera-Cornejo","orcid":null,"position":9,"is_corresponding":false},{"id":411808,"name":"Carlos Cabello-Gutiérrez","orcid":"0000-0002-3192-8915","position":10,"is_corresponding":false},{"id":411809,"name":"Manuel Castillejos‐López","orcid":"0000-0001-8689-9755","position":11,"is_corresponding":false},{"id":411810,"name":"Andrés Hernández","orcid":"0000-0002-8759-8863","position":12,"is_corresponding":false},{"id":411811,"name":"Nora E. 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