{"doi":"10.1016/j.ijid.2020.01.017","title":"Influenza A-associated severe pneumonia in hospitalized patients: Risk factors and NAI treatments","abstract":"OBJECTIVE: The risk factors and the impact of NAI treatments in patients with severe influenza A-associated pneumonia remain unclear. METHODS: A multicenter, retrospective, observational study was conducted in Zhejiang, China during a severe influenza epidemic in August 2017-May 2018. Clinical records of patients (>14 y) hospitalized with laboratory-confirmed influenza A virus infection and who developed severe pneumonia were compared to those with mild-to-moderate pneumonia. Risk factors related to pneumonia severity and effects of NAI treatments (monotherapy and combination of peramivir and oseltamivir) were analyzed. RESULTS: 202 patients with influenza A-associated severe pneumonia were enrolled, of whom 84 (41.6%) had died. Male gender (OR = 1.782; 95% CI: 1.089-2.917; P = 0.022), chronic pulmonary disease (OR = 2.581; 95% CI: 1.447-4.603; P = 0.001) and diabetes mellitus (OR = 2.042; 95% CI: 1.135-3.673; P = 0.017) were risk factors related to influenza A pneumonia severity. In cox proportional hazards model, severe pneumonia patients treated with double dose oseltamivir (300mg/d) had a better survival rate compared to those receiving a single dose (150 mg/d) (HR = 0.475; 95%CI: 0.254-0.887; P = 0.019). However, different doses of peramivir (300 mg/d vs. 600 mg/d) and combination therapy (oseltamivir-peramivir vs. monotherapy) showed no differences in 60-day mortality (P = 0.392 and P = 0.658, respectively). CONCLUSIONS: Patients with male gender, chronic pulmonary disease, or diabetes mellitus were at high risk of developing severe pneumonia after influenza A infection. Double dose oseltamivir might be considered in treating influenza A-associated severe pneumonia.","journal":"International Journal of Infectious Diseases","year":2020,"id":59158,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311120,"name":"Shufa Zheng","orcid":"0000-0003-2536-1008","position":1,"is_corresponding":false},{"id":311121,"name":"Xiaochen Wang","orcid":"0000-0001-8911-3690","position":2,"is_corresponding":false},{"id":251074,"name":"Sijia Liu","orcid":"0000-0001-9763-1164","position":3,"is_corresponding":false},{"id":311122,"name":"Jiaqi Bao","orcid":"0009-0002-1982-0458","position":4,"is_corresponding":false},{"id":311123,"name":"Fei Yu","orcid":"0000-0001-6332-4326","position":5,"is_corresponding":false},{"id":311124,"name":"Wei Wu","orcid":"0000-0003-2892-5956","position":6,"is_corresponding":false},{"id":311125,"name":"Xianjun Wang","orcid":"0009-0006-7179-6749","position":7,"is_corresponding":false},{"id":311126,"name":"Bo Shen","orcid":"0000-0001-6771-2406","position":8,"is_corresponding":false},{"id":311127,"name":"Tieli Zhou","orcid":"0000-0002-2171-4710","position":9,"is_corresponding":false},{"id":311128,"name":"Zhigang Zhao","orcid":"0000-0003-4110-4802","position":10,"is_corresponding":false},{"id":311129,"name":"Yiping Wang","orcid":"0000-0002-3178-3752","position":11,"is_corresponding":false},{"id":312935,"name":"Ruchang Chen","orcid":null,"position":12,"is_corresponding":false},{"id":311130,"name":"Wei Wang","orcid":"0000-0002-5539-4532","position":13,"is_corresponding":false},{"id":311131,"name":"Jianbo Ma","orcid":"0000-0003-0046-0835","position":14,"is_corresponding":false},{"id":311132,"name":"Yongcheng Li","orcid":"0000-0003-1507-6211","position":15,"is_corresponding":false},{"id":311133,"name":"Xiaoyan Wu","orcid":"0000-0002-1066-4148","position":16,"is_corresponding":false},{"id":312936,"name":"Weifeng Shen","orcid":null,"position":17,"is_corresponding":false},{"id":312937,"name":"Fuyi Xie","orcid":null,"position":18,"is_corresponding":false},{"id":256371,"name":"Dhanasekaran Vijaykrishna","orcid":"0000-0003-3293-6279","position":19,"is_corresponding":false},{"id":311134,"name":"Yu Chen","orcid":"0000-0003-4560-8434","position":20,"is_corresponding":false},{"id":312934,"name":"Qianda Zou","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T21:07:59.189921Z","pmid":"31978583","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}