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Mathematical modeling of these very rapid rates of T cell escape showed that the contribution of CD8+ T cell mediated killing of productively infected cells was earlier and significantly greater than previously described; calculating that T cells in acute HIV-1 kill as much as 35% of virus-infected cells per day. These first T cell responses often waned rapidly following virus escape leaving, or being succeeded by, T cell responses to epitopes that escaped slowly or were invariant. Here, we present data from an additional 10 patients that extend these observations and demonstrate that early rapid escape from primary HIV-1-specific T cell responses occurs in the majority of patients studied, suggesting that T cells are major contributors to the control of viremia in acute HIV-1 infection. Additional data will be presented on functional avidity, phenotyping and kinetics across the group over the first 6 months of infection. Discussion will focus on how these results, together with the studies investigating new immunogens may direct more effective design of HIV-1 T cell vaccines. Supported by the NIAD Center for HIV/AIDS Vaccine Immunology grant # U19 AI067854. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20725694","pmcid":null,"openalex_id":"https://openalex.org/W1972521954","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"5U19AI067854-04","title":"Structural Biology Core"}],"total_grants":1,"fwci":0.0,"citation_percentile":0.05279568,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://doi.org/10.1016/j.ijid.2010.02.1528","host_type":"journal"},{"url":"https://doi.org/10.1016/j.ijid.2010.02.1528","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1201971210015687?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1201971210015687?httpAccept=text/plain","host_type":"publisher"},{"url":"https://ora.ox.ac.uk/objects/uuid:e12c726b-4d44-4392-a1c4-db6f386dc37c","host_type":"repository"},{"url":"http://www.ijidonline.com/article/S1201971210015687/pdf","host_type":""},{"url":"http://dx.doi.org/10.1016/j.ijid.2010.02.1528","host_type":""},{"url":"https://dx.doi.org/10.1016/j.ijid.2010.02.1528","host_type":""}],"fields_of_study":["HIV Research and Treatment","Immune Cell Function and Interaction","vaccines and immunoinformatics approaches","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Viremia","T cell","Virology","Immunology","CD8","Virus","Immune system","Biology","Viral replication","Cytotoxic T cell","Immunity","Epitope","Avidity","Cd4 t cell","Antibody","In vitro","Genetics","Microbiology (medical)","Infectious Diseases"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T12:18:13.443007Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}