{"doi":"10.1016/j.ijchp.2023.100421","title":"The modulation effects of the mind-body and physical exercises on the basolateral amygdala-temporal pole pathway on individuals with knee osteoarthritis","abstract":"Background/Objective: To investigate the modulatory effects of different physical exercise modalities on connectivity of amygdala subregions and its association with pain symptoms in patients with knee osteoarthritis (KOA). Methods: 140 patients with KOA were randomly allocated either to the Tai Chi, Baduanjin, Stationary cycling, or health education group and conducted a 12 week-long intervention in one of the four groups. The behavioral, magnetic resonance imaging (MRI), and blood data were collected at baseline and the end of the study. Results: Compared to the control group, all physical exercise modalities lead to significant increases in Knee Injury and Osteoarthritis Outcome Score (KOOS) pain score (pain relief) and serum Programmed Death-1 (PD-1) levels. Additionally, all physical exercise modalities resulted in decreased resting state functional connectivity (rsFC) of the basolateral amygdala (BA)-temporal pole and BA-medial prefrontal cortex (mPFC). The overlapping BA-temporal pole rsFC observed in both Tai Chi and Baduanjin groups was significantly associated with pain relief, while the BA-mPFC rsFC was significantly associated with PD-1 levels. In addition, we found increased fractional anisotropy (FA) values, a measurement of water diffusion anisotropy of tissue that responded to changes in brain microstructure, within the mind-body exercise groups' BA-temporal pole pathway. The average FA value of this pathway was positively correlated with KOOS pain score at baseline across all subjects. Conclusions: Our findings suggest that physical exercise has the potential to modulate both functional and anatomical connectivity of the amygdala subregions, indicating a possible shared pathway for various physical exercise modalities.","journal":"International Journal of Clinical and Health Psychology","year":2023,"id":347102,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9459,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1088545,"name":"Weilin Liu","orcid":"0000-0001-7212-3147","position":1,"is_corresponding":false},{"id":485060,"name":"Jia Huang","orcid":"0000-0002-0976-9882","position":2,"is_corresponding":false},{"id":499188,"name":"Yajun Wang","orcid":"0000-0002-7557-5883","position":3,"is_corresponding":false},{"id":1089033,"name":"Baoru Zhao","orcid":null,"position":4,"is_corresponding":false},{"id":1089034,"name":"Peiling Zeng","orcid":null,"position":5,"is_corresponding":false},{"id":1089035,"name":"Guiyan Cai","orcid":null,"position":6,"is_corresponding":false},{"id":1088546,"name":"Ruilin Chen","orcid":"0000-0002-8223-5481","position":7,"is_corresponding":false},{"id":396849,"name":"Kun Hu","orcid":"0000-0003-0350-3132","position":8,"is_corresponding":false},{"id":1089036,"name":"Youxue Tu","orcid":null,"position":9,"is_corresponding":false},{"id":1088547,"name":"Meiqin Lin","orcid":"0000-0002-6798-9613","position":10,"is_corresponding":false},{"id":289036,"name":"Jian Kong","orcid":"0000-0002-2744-6067","position":11,"is_corresponding":false},{"id":939350,"name":"Jing Tao","orcid":"0000-0002-4895-2065","position":12,"is_corresponding":false},{"id":939351,"name":"Lidian Chen","orcid":"0000-0002-8699-0839","position":13,"is_corresponding":false},{"id":225232,"name":"Jiao Liu","orcid":"0000-0003-0304-241X","position":0,"is_corresponding":true}],"reference_count":112,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:11:57.720122Z","pmid":"38077287","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}