{"doi":"10.1016/j.ijcha.2025.101602","title":"Sudden cardiac death associated with fatty liver disease","abstract":"Background: Fatty liver disease or steatotic liver disease (SLD) affects 25% of the global population and has been associated with heart disease. However, there is a lack of postmortem studies in the context of sudden cardiac death (SCD). Objectives: To investigate the relationship between SLD and SCD. Methods: A post-mortem case-case study was conducted in victims of SCD from an ongoing community-based study in Southern California (Ventura, CA, 2015-2023). Diagnosis of SLD was determined from post-mortem liver histopathology reports. For each patient, demographic variables, laboratory values, and presence of co-morbidities were ascertained from medical records and were compared between patients with and without SLD. Results: Of 162 individuals with SCD, there were 101 SLD cases and 61 without SLD. Individuals with SLD were found to have higher BMI (31.6 ± 7.6 vs. 26.7 ± 5.7, p < 0.001), higher prevalence of heavy drinking (28 % vs. 12 %, p = 0.008), heavier liver weights (2433.6 g ± 940.6 vs 1934.7 g ± 505.3, p < 0.001), and were more often Hispanic (37 vs. 18 %, p = 0.01). Patients with SLD had lower prevalence of coronary artery disease (CAD) (49 % vs. 70 %). Multivariable logistic regression analysis showed that CAD was a negative predictor of SCD with SLD (OR = 0.35, 95 % CI 0.14 - 0.83). Conclusion: Among adults with SCD, SLD was associated with higher prevalence of Hispanic ethnicity and lower prevalence of CAD. Given the major rise in SLD burden, these ethnicity-based differences as well as the specific nature of non-ischemic SCD etiologies warrant urgent further investigation.","journal":"IJC Heart & Vasculature","year":2025,"id":537816,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7426,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1422238,"name":"Thien Tan Tri Tai Truyen","orcid":"0000-0001-8129-2532","position":1,"is_corresponding":false},{"id":488564,"name":"Audrey Uy‐Evanado","orcid":"0000-0002-1362-9663","position":2,"is_corresponding":false},{"id":685942,"name":"Arayik Sargsyan","orcid":null,"position":3,"is_corresponding":false},{"id":685234,"name":"Harpriya Chugh","orcid":"0000-0002-6581-4246","position":4,"is_corresponding":false},{"id":1062835,"name":"Christopher Young","orcid":"0000-0002-1677-7178","position":5,"is_corresponding":false},{"id":1424534,"name":"Sean Hurst","orcid":null,"position":6,"is_corresponding":false},{"id":704631,"name":"Christina Y. Miyake","orcid":"0000-0002-3120-9320","position":7,"is_corresponding":false},{"id":488563,"name":"Kyndaron Reinier","orcid":"0000-0002-2588-6827","position":8,"is_corresponding":false},{"id":23013,"name":"Sumeet S. Chugh","orcid":"0000-0002-4417-5326","position":9,"is_corresponding":false},{"id":1424533,"name":"Jonathan Vo","orcid":null,"position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:52:16.891390Z","pmid":"39867850","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}