{"doi":"10.1016/j.ifset.2016.11.015","title":"A combined treatment of UV-assisted TiO2 photocatalysis and high hydrostatic pressure to inactivate internalized murine norovirus","abstract":null,"journal":"Innovative Food Science & Emerging Technologies","year":2017,"id":635483,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1648731,"name":"Hafiz Muhammad Shahbaz","orcid":null,"position":1,"is_corresponding":false},{"id":1648732,"name":"Daseul Park","orcid":null,"position":2,"is_corresponding":false},{"id":1648733,"name":"Soyoung Chun","orcid":null,"position":3,"is_corresponding":false},{"id":1648734,"name":"Wooseong Lee","orcid":null,"position":4,"is_corresponding":false},{"id":1648735,"name":"Jong-Won Oh","orcid":null,"position":5,"is_corresponding":false},{"id":1648736,"name":"Dong-Un Lee","orcid":null,"position":6,"is_corresponding":false},{"id":670989,"name":"Jiyong Park","orcid":"0000-0002-3225-4510","position":7,"is_corresponding":false},{"id":1648730,"name":"Sun-Hyoung Kim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A combined treatment of UV-assisted TiO2 photocatalysis and high hydrostatic pressure to inactivate internalized murine norovirus","abstract":"Human norovirus (HuNoV) is a major cause of foodborne illness associated with shellfish consumption. A solidified agar matrix (SAM) was experimentally prepared using agar solution for inactivation of murine norovirus (MNV-1) as a surrogate for HuNoV in a simulation model approach. MNV-1 was injected inside the SAM for virus internalization, and the effects of single and combined UV-assisted TiO2 photocatalysis (UVTP) and high hydrostatic pressure (HHP) treatments were determined. The internalized MNV-1 were reduced by 2.9-log10 and 3.5-log10, respectively, after single treatments of UVTP (4.5mW/cm2, 10min) and HHP (500MPa, 5min, ambient temperature). However, the internalized MNV-1 was reduced by 5.5-log10 (below the detection limit) when UVTP was followed by HHP, indicating a synergistic inactivation effect. Analysis of viral morphology, proteins, and genomic RNA allowed elucidation of mechanisms involved in the synergistic antiviral activity of combined treatments, which appeared to disrupt the MNV-1 structure and damage both the capsid protein and genomic RNA.HHP treatment of raw oysters has proved commercially successful, but there is a less evidence available regarding the potential of HHP for inactivation of localized viruses present inside foods. A sequential combination of UV-assisted TiO2 photocatalysis (UVTP) and high hydrostatic pressure (HHP) achieved significantly higher inactivation of localized virus compared to individual treatments due to a synergistic mechanism. An experimentally prepared model food system was found useful to simulate foods with morphological variations and unpredictable viral internalization patterns. This UVTP-HHP combined treatment for inactivation of localized MNV-1 can be useful for disinfection of raw oysters and other similar foods.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W2558922848","authors":[],"funders":[{"funder_name":"Ministry of Agriculture, Food and Rural Affairs","grant_id":"111139-3","title":null}],"total_grants":1,"fwci":1.0724,"citation_percentile":0.77970535,"influential_citations":0,"citation_trend":[{"year":2018,"count":4},{"year":2019,"count":1},{"year":2020,"count":8},{"year":2021,"count":8},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1466856416307500?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1466856416307500?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ifset.2016.11.015","host_type":"journal"}],"fields_of_study":["Viral gastroenteritis research and epidemiology","Infection Control and Ventilation","Virus-based gene therapy research"],"mesh_terms":[],"keywords":["Murine norovirus","Norovirus","Hydrostatic pressure","Capsid","Chemistry","Internalization","Microbiology","Biotinylation","Bacteriophage MS2","Food science","High pressure","Virus","Virology","Bacteriophage","Biology","Biochemistry","Gene","Cell","Escherichia coli"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:10:32.171639Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}