{"doi":"10.1016/j.ifacol.2025.01.156","title":"Personalized Artificial Pancreas for Glucose Regulation in People with Diabetes","abstract":"Artificial pancreas (AP) is a cyber-physical system used by many people with type 1 diabetes. Current APs used in free living rely on feedback control based on continuous glucose monitoring data. Information on major disturbances (meals, exercise) to blood glucose concentration (BGC) is entered manually. A multivariable AP (mvAP) is developed for fully automated AP that can mitigate the effects of meals and physical activities by measuring and interpreting several physiological variables (feedforward control). It uses physiological variables and a personalized, recursively updated metabolic model of the user with a model predictive controller (MPC) to adjust insulin infusion flow rates. To ensure the accuracy of the model and a precise estimation of the model input disturbances, we use recursive least squares and unscented Kalman filter to concurrently estimate the model states and parameters. Support vector regression is utilized to forecast the disturbances over the future horizon to improve the accuracy of predicting future BGC values used by the MPC. Simulations and results of an exploratory clinical experiment are reported to illustrate the performance of the mvAP system.","journal":"IFAC-PapersOnLine","year":2024,"id":460679,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344846,"name":"Mudassir Rashid","orcid":"0000-0003-4521-0872","position":1,"is_corresponding":false},{"id":1288812,"name":"Máté Siket","orcid":"0000-0002-4425-5588","position":2,"is_corresponding":false},{"id":906161,"name":"Mahmoud Abdel-Latif","orcid":"0000-0002-4237-847X","position":3,"is_corresponding":false},{"id":735961,"name":"Andrew Shahidehpour","orcid":"0000-0002-6703-9677","position":4,"is_corresponding":false},{"id":344851,"name":"Ali Çınar","orcid":"0000-0002-1607-9943","position":5,"is_corresponding":false},{"id":1050760,"name":"Mohammad Ahmadasas","orcid":"0009-0002-8078-8709","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T02:04:07.925246Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}