{"doi":"10.1016/j.humpath.2011.02.014","title":"Immunohistochemical expression of prostate tumor overexpressed 1 in cystoprostatectomies with incidental and insignificant prostate cancer.","abstract":null,"journal":"Human Pathology","year":2011,"id":624202,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1613478,"name":"Francesca Barbisan","orcid":null,"position":1,"is_corresponding":false},{"id":1613479,"name":"Alfredo Santinelli","orcid":null,"position":2,"is_corresponding":false},{"id":1581853,"name":"Antonio Lopez-Beltran","orcid":null,"position":3,"is_corresponding":false},{"id":590500,"name":"Liang Cheng","orcid":"0000-0003-4105-1763","position":4,"is_corresponding":false},{"id":1581854,"name":"Marina Scarpelli","orcid":null,"position":5,"is_corresponding":false},{"id":1581850,"name":"Rodolfo Montironi","orcid":null,"position":6,"is_corresponding":false},{"id":1581852,"name":"Roberta Mazzucchelli","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immunohistochemical expression of prostate tumor overexpressed 1 in cystoprostatectomies with incidental and insignificant prostate cancer.","abstract":"Prostate tumor overexpressed 1 was recently identified as a novel gene and protein during a differential display screening for genes overexpressed in prostate cancer. It has been suggested that overexpression of prostate tumor overexpressed 1 can contribute to the proliferative status of prostate tumor cells and, thus, to their biologic behavior. Prostate tumor overexpressed 1 and Ki-67 were immunohistochemically evaluated in prostate cancer, high-grade prostatic intraepithelial neoplasia, and normal-looking epithelium in 20 cystoprostatectomies and 20 radical prostatectomies with pT2a Gleason score 6 prostate cancer. The aim was to see whether there were differences in marker expression between cystoprostatectomies and radical prostatectomies. The proportions of prostate tumor overexpressed 1- and Ki-67-positive cells in the cystoprostatectomies and radical prostatectomies increased from normal-looking epithelium through high-grade prostatic intraepithelial neoplasia, away from and adjacent to prostate cancer, to prostate cancer. Prostate tumor overexpressed 1 expression in prostate cancer in cystoprostatectomies was lower than in radical prostatectomies, the differences being significant; there were significant differences in Ki-67 indices. In conclusion, our findings related to prostate tumor overexpressed 1 expression in high-grade prostatic intraepithelial neoplasia, evaluated adjacent and away from prostate cancer, and in incidental and clinical cancers give further support to the concept of field effect in prostatic carcinogenesis as well as to differences in the process of prostatic carcinogenesis between cystoprostatectomies and radical prostatectomies.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21676431","pmcid":null,"openalex_id":"https://openalex.org/W2019340165","authors":[],"funders":[],"total_grants":0,"fwci":1.5816,"citation_percentile":0.83222879,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2014,"count":4},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":3},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0046817711001122?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0046817711001122?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.humpath.2011.02.014","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21676431","host_type":"repository"},{"url":"http://hdl.handle.net/11566/66131","host_type":"repository"}],"fields_of_study":["Prostate Cancer Treatment and Research","Cancer-related Molecular Pathways","Cancer-related gene regulation","Adult","Aged","Aged, 80 and over","Biomarkers, Tumor","Cell Proliferation","Cystectomy","Epithelium","Gene Expression Regulation, Neoplastic","Humans","Immunohistochemistry","Incidental Findings","Ki-67 Antigen","Male","Middle Aged","Neoplasm Grading","Neoplasm Proteins","Prostate","Prostatectomy","Prostatic Intraepithelial Neoplasia","Prostatic Neoplasms","Seminal Vesicles","Adaptor Proteins, Signal Transducing"],"mesh_terms":["Adult","Aged","Aged, 80 and over","Epithelium","Humans","Immunohistochemistry","Male","Middle Aged","Neoplasm Proteins","Prostate","Prostatectomy","Prostatic Neoplasms","Seminal Vesicles","Biomarkers, Tumor","Cystectomy","Gene Expression Regulation, Neoplastic","Prostatic Intraepithelial Neoplasia","Ki-67 Antigen","Incidental Findings","Adaptor Proteins, Signal Transducing","Cell Proliferation","Neoplasm Grading"],"keywords":["Prostate cancer","Prostate","Intraepithelial neoplasia","PCA3","Medicine","High-grade prostatic intraepithelial neoplasia","Carcinogenesis","Pathology","Cancer","Immunohistochemistry","Oncology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T03:02:56.116673Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}