{"doi":"10.1016/j.hrthm.2021.03.016","title":"Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone","abstract":"BACKGROUND: Although atrial fibrillation ablation is increasingly used for rhythm control therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination with ablation. The effectiveness of AADs is highly variable. Previous work from our group suggests that alterations in atrial resting membrane potential (RMP) induced by low Pitx2 expression could explain the variable effect of flecainide. OBJECTIVE: The purpose of this study was to assess whether alterations in atrial/cardiac RMP modify the effectiveness of multiple clinically used AADs. METHODS: 1.5, primary murine atrial cardiac myocytes, and murine hearts with reduced Pitx2c. RESULTS: hearts, which have a more positive RMP compared to wild type. CONCLUSION: Atrial RMP modifies the effectiveness of several clinically used AADs. Dronedarone is more sensitive to changes in atrial RMP than flecainide or propafenone. Identifying and modifying atrial RMP may offer a novel approach to enhancing the effectiveness of AADs or personalizing AAD selection.","journal":"Heart Rhythm","year":2021,"id":186631,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":744861,"name":"Priyanka Saxena","orcid":"0000-0003-4772-1502","position":1,"is_corresponding":false},{"id":744862,"name":"S. Nashitha Kabir","orcid":"0000-0003-1811-8683","position":2,"is_corresponding":false},{"id":744863,"name":"Christopher O’Shea","orcid":"0000-0003-3030-7364","position":3,"is_corresponding":false},{"id":745482,"name":"Stefan Kuhlmann","orcid":null,"position":4,"is_corresponding":false},{"id":745483,"name":"Suranjana Gupta","orcid":null,"position":5,"is_corresponding":false},{"id":745484,"name":"Dannie Fobian","orcid":null,"position":6,"is_corresponding":false},{"id":744864,"name":"Clara Apicella","orcid":"0009-0008-9564-3039","position":7,"is_corresponding":false},{"id":744865,"name":"Molly O’Reilly","orcid":"0000-0003-1936-5838","position":8,"is_corresponding":false},{"id":744866,"name":"Fahima Syeda","orcid":"0000-0002-0277-2552","position":9,"is_corresponding":false},{"id":295758,"name":"Jasmeet S. Reyat","orcid":"0000-0003-3247-9186","position":10,"is_corresponding":false},{"id":725633,"name":"Godfrey L. Smith","orcid":"0000-0003-4821-9741","position":11,"is_corresponding":false},{"id":744867,"name":"Antony J. Workman","orcid":"0000-0002-5429-8303","position":12,"is_corresponding":false},{"id":744868,"name":"Davor Pavlović","orcid":"0000-0002-3171-3551","position":13,"is_corresponding":false},{"id":295761,"name":"Larissa Fabritz","orcid":"0000-0002-9241-1733","position":14,"is_corresponding":false},{"id":2642,"name":"Paulus Kirchhof","orcid":"0000-0002-1881-0197","position":15,"is_corresponding":false},{"id":44931,"name":"Andrew P. Holmes","orcid":"0000-0001-9270-9401","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T23:48:46.850806Z","pmid":"33737232","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}