{"doi":"10.1016/j.hroo.2023.06.005","title":"Optimal conditions for high-power, short-duration radiofrequency ablation using a novel, flexible-tipped, force-sensing catheter","abstract":"Background High-power, short-duration (HPSD) radiofrequency ablation (RFA) reduces procedure time; however, safety and efficacy thresholds vary with catheter design. Objective The study sought to determine optimal HPSD ablation conditions with a novel flexible-tipped, contact force–sensing RFA catheter. Methods RFA lesions were created in thigh muscle (16 swine) over a range of conditions (51–82 W, 2–40 g, 8–40 mL/min irrigation). An intracardiac study was performed (12 swine) to characterize steam pop thresholds. Lesions were created in a second intracardiac study (14 swine, n=290 pulmonary vein isolation [PVI] lesions) with combinations of radiofrequency power, duration, and contact force. PVI was tested, animals were sacrificed, and lesions were measured. Results The likelihood of coagulation formation in the thigh model was <20% when power was ≤79 W, when contact force was ≤40 g, when duration was ≤11 seconds, and when irrigation rates were 8 to 40 mL/min. The impact of contact force on lesion safety and efficacy was more pronounced using HPSD (60 W/8 seconds) compared with conventional ablation (30 W/45 seconds) ( P = .038). During PVI, focal atrial lesions ranged in width from 4.2 to 12.5 mm and were transmural 80.8% of the time. PVI was achieved in 13 of 14 veins. Logistic regression identified that the optimal parameters for radiofrequency application were 60 to 70 W with a duration <8 seconds and <15 g contact force. Conclusions Optimal HPSD lesions with this this flexible-tipped, force-sensing RFA catheter were created at 60 to 70 W for <8 seconds with <15 g contact force. Chronic studies are ongoing to assess radiofrequency parameter refinements and long-term lesion durability using these conditions.","journal":"Heart Rhythm O2","year":2023,"id":369115,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340989,"name":"Amish S. Dave","orcid":null,"position":1,"is_corresponding":false},{"id":1127832,"name":"Douglas Holmes","orcid":"0000-0002-3125-9483","position":2,"is_corresponding":false},{"id":1127833,"name":"Jeffrey R. Winterfield","orcid":"0000-0002-6827-8506","position":3,"is_corresponding":false},{"id":1128182,"name":"John H. Tranter","orcid":null,"position":4,"is_corresponding":false},{"id":1128183,"name":"Catherine Pipenhagen","orcid":null,"position":5,"is_corresponding":false},{"id":1128184,"name":"L. Boyce Moon","orcid":null,"position":6,"is_corresponding":false},{"id":1128185,"name":"Nicholas M. Ambrosius","orcid":null,"position":7,"is_corresponding":false},{"id":1128186,"name":"Jed Overmann","orcid":null,"position":8,"is_corresponding":false},{"id":1128187,"name":"Hana Boudlali","orcid":null,"position":9,"is_corresponding":false},{"id":1128188,"name":"Riki Thao","orcid":null,"position":10,"is_corresponding":false},{"id":1128189,"name":"Chris Geurkink","orcid":null,"position":11,"is_corresponding":false},{"id":1128190,"name":"Zada Thamavong","orcid":null,"position":12,"is_corresponding":false},{"id":1128191,"name":"James A. Jensen","orcid":null,"position":13,"is_corresponding":false},{"id":1128192,"name":"Jeffrey Fish","orcid":null,"position":14,"is_corresponding":false},{"id":70475,"name":"Jonathan P. Piccini","orcid":"0000-0003-0772-2404","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:15:28.704894Z","pmid":"37520016","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}