{"doi":"10.1016/j.gore.2022.101040","title":"High pre-treatment neutrophil-to-lymphocyte ratio as a prognostic marker for worse survival in patients with recurrent/metastatic cervical cancer treated with immune checkpoint inhibitors","abstract":"Objective: To evaluate the association between pre-treatment neutrophil-to-lymphocyte ratio (NLR) and survival outcomes among patients with recurrent/metastatic cervical cancer treated with PD-1/PD-L1 inhibitors. Methods: A retrospective analysis of patients with recurrent/metastatic cervical cancer treated with PD-1/PD-L1 inhibitors from 2016 to 2021 was conducted. Progression free survival (PFS) and overall survival (OS) outcomes were assessed for patients stratified by NLR (<8 vs ≥ 8) utilizing Kaplan-Meier method. Univariable analysis was performed to compare baseline characteristics between the two groups. Results: A total of 49 patients were included in analysis. A majority of patients had squamous cell histology (57%), were PD-L1 positive (55%), received ≤ 1 prior lines of systemic therapy (57%), and had distant metastatic disease at the time of treatment (69%). The groups were well-balanced with respect to age, race, histology, smoking status, PD-L1 positivity, prior lines of treatment (≤1 vs > 1), prior radiation therapy, ECOG performance status, and disease distribution for patients with a NLR < 8 (n = 35) compared to those with a NLR ≥ 8 (n = 14). A pre-treatment NLR of < 8 was associated with improved survival (p < 0.01), with 57% (95% CI: 41%, 78%) probability of survival at one year compared to 26% (95% CI: 10%, 66%) for those with NLR ≥ 8. No statistically significant differences in probability of PFS at 1 year were seen between NLR < 8 compared to those with NLR ≥ 8 (p = 0.70). Conclusions: Pre-treatment NLR may hold prognostic value for patients with metastatic/recurrent cervical cancer treated with PD-1/PD-L1 inhibitors, with NLR < 8 associated with improved survival.","journal":"Gynecologic Oncology Reports","year":2022,"id":267635,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9659,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":912324,"name":"David A. Mix Barrington","orcid":"0000-0002-5958-2792","position":1,"is_corresponding":false},{"id":928699,"name":"Morgan Brown","orcid":"0000-0002-8927-5830","position":2,"is_corresponding":false},{"id":928700,"name":"Lynette Gonzalez","orcid":"0009-0008-0813-2258","position":3,"is_corresponding":false},{"id":928701,"name":"Jae Suk Baek","orcid":"0000-0002-0083-8730","position":4,"is_corresponding":false},{"id":929237,"name":"Allison Huffman","orcid":null,"position":5,"is_corresponding":false},{"id":898950,"name":"Jason Benedict","orcid":"0000-0001-5982-7764","position":6,"is_corresponding":false},{"id":445478,"name":"Floor Backes","orcid":"0000-0002-9225-6913","position":7,"is_corresponding":false},{"id":402042,"name":"Laura Chambers","orcid":"0000-0002-3773-7060","position":8,"is_corresponding":false},{"id":445477,"name":"David E. Cohn","orcid":"0000-0002-3036-6172","position":9,"is_corresponding":false},{"id":918255,"name":"Larry J. Copeland","orcid":"0000-0001-6204-0962","position":10,"is_corresponding":false},{"id":642405,"name":"Casey Cosgrove","orcid":"0009-0003-1056-9938","position":11,"is_corresponding":false},{"id":544078,"name":"Christa Nagel","orcid":"0000-0001-6454-6246","position":12,"is_corresponding":false},{"id":258149,"name":"David M. O’Malley","orcid":"0000-0002-2828-0177","position":13,"is_corresponding":false},{"id":928702,"name":"Kristin Bixel","orcid":"0000-0003-2414-3375","position":14,"is_corresponding":false},{"id":928698,"name":"Corinne Calo","orcid":"0000-0002-8995-4972","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:27:06.198948Z","pmid":"35855965","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}