{"doi":"10.1016/j.gore.2021.100808","title":"Radiation therapy for vaginal and perirectal lesions in recurrent ovarian cancer","abstract":"The role for localized radiation to treat ovarian cancer (OC) patients with locally recurrent vaginal/perirectal lesions remains unclear, though we hypothesize these patients may be salvaged locally and gain long-term survival benefit. We describe our institutional outcomes using intensity modulated radiation therapy (IMRT) +/- high-dose rate (HDR) brachytherapy to treat this population. Our primary objectives were to evaluate complete response rates of targeted lesions after radiation and calculate our 5-year in-field control (IFC) rate. Secondary objectives were to assess radiation-related toxicities, chemotherapy free-interval (CFI), as well as post-radiation progression-free (PFS) and overall survival (OS). PFS and OS were defined from radiation start to either progression or death/last follow-up, respectively. This was a heavily pre-treated cohort of 17 recurrent OC patients with a median follow-up of 28.4 months (range 4.5-166.4) after radiation completion. 52.9% had high-grade serous histology and 4 (23.5%) had isolated vaginal/perirectal disease. Four (23.5%) patients had in-field failures at 3.7, 11.2, 24.5, and 27.5 months after start of radiation, all treated with definitive dosing of radiation therapy. Patients who were platinum-sensitive prior to radiation had similar median PFS (6.5 vs. 13.4 months, log-rank p = 0.75), but longer OS (71.1 vs 18.8 months, log-rank p = 0.05) than their platinum-resistant counterparts. Excluding patients with low-grade histology or who were treated with palliative radiation, median CFI was 14.2 months (range 4.7 - 33.0). Radiation was well tolerated with 2 (12.0%) experiencing grade 3/4 gastrointestinal/genitourinary toxicities. In conclusion, radiation to treat locally recurrent vaginal/perirectal lesions in heavily pre-treated OC patients is safe and may effectively provide IFC.","journal":"Gynecologic Oncology Reports","year":2021,"id":209434,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":275039,"name":"Jennifer Stanley","orcid":"0000-0002-1650-2158","position":1,"is_corresponding":false},{"id":581713,"name":"Michael Toboni","orcid":"0000-0002-2199-9760","position":2,"is_corresponding":false},{"id":227904,"name":"Julie K. Schwarz","orcid":"0000-0003-2407-7531","position":3,"is_corresponding":false},{"id":44395,"name":"F. Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":581717,"name":"Andrea R. Hagemann","orcid":"0000-0002-3484-0046","position":5,"is_corresponding":false},{"id":581719,"name":"Katherine C. Fuh","orcid":"0000-0002-7693-2694","position":6,"is_corresponding":false},{"id":294595,"name":"Premal H. Thaker","orcid":"0000-0002-0568-6959","position":7,"is_corresponding":false},{"id":552818,"name":"Carolyn K. McCourt","orcid":"0000-0003-2229-8971","position":8,"is_corresponding":false},{"id":1723,"name":"David G. Mutch","orcid":"0000-0002-6921-1581","position":9,"is_corresponding":false},{"id":581718,"name":"Matthew A. Powell","orcid":"0000-0002-9001-3862","position":10,"is_corresponding":false},{"id":356779,"name":"Dineo Khabele","orcid":"0000-0002-5151-5210","position":11,"is_corresponding":false},{"id":477569,"name":"Lindsay M. Kuroki","orcid":"0000-0002-2141-7310","position":12,"is_corresponding":false},{"id":797032,"name":"Elizabeth A. Johns","orcid":"0000-0002-4150-3830","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-18T23:52:05.171356Z","pmid":"34169134","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}