{"doi":"10.1016/j.gene.2020.145246","title":"Review on mechanistic strategy of gene therapy in the treatment of disease","abstract":null,"journal":"Gene","year":2021,"id":589461,"datarank":1.4253081766877842,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"self_citation_contribution":0.5806801516361837,"citation_network_contribution":0.8446280250516004,"self_endowment_contribution":0.5806801516361837,"citer_contribution":0.8446280250516004,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":44,"citers_with_citation_signal":35,"citers_with_endowment":35,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1508169,"name":"Sulaiman M. 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In this review, we tried to cover all aspects of gene therapy studies; starting with the concept of gene, its treatment, gene delivery system and types, clinical trial either by vitro or In-Vivo -Clinical Trials and Clinical Intoxication of Gene Therapy. Therefore, the promise of successful treatment with gene therapy could positively affect millions of lives. The main aim of this review is to address the principles of gene therapy, various methods involved in the gene therapy, clinical applications and its merits and demerits.","is_dataset_classified":null,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33098937","pmcid":null,"openalex_id":"https://openalex.org/W3094526112","authors":[],"funders":[],"total_grants":0,"fwci":2.0884,"citation_percentile":0.8813261,"influential_citations":0,"citation_trend":[{"year":2021,"count":4},{"year":2022,"count":12},{"year":2023,"count":12},{"year":2024,"count":12},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S037811192030915X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S037811192030915X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.gene.2020.145246","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33098937","host_type":"repository"}],"fields_of_study":["CRISPR and Genetic Engineering","Virus-based gene therapy research","RNA Interference and Gene Delivery","Gene Transfer Techniques","Genetic Therapy","Genetic Vectors","Humans"],"mesh_terms":["Genetic Vectors","Humans","Genetic Therapy","Gene Transfer Techniques"],"keywords":["Genetic enhancement","Biology","Gene delivery","Clinical trial","Gene","Disease","Viral vector","Gene transfer","Vectors in gene therapy","Ex vivo","Vector (molecular biology)","Computational biology","Bioinformatics","In vivo","Biotechnology","Genetics","Medicine","Pathology","Recombinant DNA","Viral","Target cells","Genetic toxicology","Stem Cells","Delivery systems","Non-viral","Clinical Intoxication","Combined Hybrid And Overexpression","Knockout Or Knockdown In Vivo"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.21382894.v1","title":"Additional file 1 of Patients’ view on gene therapy development for lysosomal storage disorders: a qualitative study","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.21382894","title":"Additional file 1 of Patients’ view on gene therapy development for lysosomal storage disorders: a qualitative study","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.21382897.v1","title":"Additional file 2 of Patients’ view on gene therapy development for lysosomal storage disorders: a qualitative study","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.21382897","title":"Additional file 2 of Patients’ view on gene therapy development for lysosomal storage disorders: a qualitative study","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-23T18:48:30.699208Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}