{"doi":"10.1016/j.gene.2020.145174","title":"A study on the role of FMR1 CGG trinucleotide repeats in Jordanian poor ovarian responders","abstract":null,"journal":"Gene","year":2021,"id":654010,"datarank":0.6051042940169657,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.11638981331374333,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.11638981331374333,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":5,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1706696,"name":"Sherin T. Shaaban","orcid":null,"position":1,"is_corresponding":false},{"id":1706698,"name":"Mohammad Al-Smadi","orcid":null,"position":2,"is_corresponding":false},{"id":1706699,"name":"Yousef Jarun","orcid":null,"position":3,"is_corresponding":false},{"id":1706700,"name":"Ahmad Maswadeh","orcid":null,"position":4,"is_corresponding":false},{"id":1706701,"name":"Nour Alhoda Alahmad","orcid":null,"position":5,"is_corresponding":false},{"id":1706702,"name":"Mohammad M Al-Talib","orcid":null,"position":6,"is_corresponding":false},{"id":1706695,"name":"Osamah Batiha","orcid":"0000-0003-2415-324X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A study on the role of FMR1 CGG trinucleotide repeats in Jordanian poor ovarian responders","abstract":"The expansion of trinucleotide CGG repeats in the promoter of fragile X mental retardation 1 (FMR1) gene is associated with fragile X and fragile X associated tremor/ataxia syndromes. While the expansion of CGG repeats has been associated with such neuro/psychiatric diseases, the contraction of CGG repeats has been recently suggested as an indication of ovarian dysfunction. This study aimed to evaluate a possible association of the short CGG repeats with poor ovarian responders (POR) and to test for a possible correlation between the CGG size and different known markers of the ovarian reserve, namely FSH, AMH, and the number of retrieved oocytes from Jordanian females. We found a significant difference between the CGG median allele size between the cases and the controls (p < 0.001), where poor ovarian responders had shorter CGG repeats compared to the healthy controls. Also, females with alleles <26 had twice the odds to be presented in the POR compared to the controls. However, we did not find a significant correlation between CGG sizes and the markers of ovarian reserve. We conclude that although low CGG repeats appear to be linked to POR, the clinical utility of FMR1 for predicting ovarian response needs further investigation.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33007370","pmcid":null,"openalex_id":"https://openalex.org/W3089954470","authors":[],"funders":[{"funder_name":"Jordan University of Science and Technology","grant_id":"","title":null}],"total_grants":1,"fwci":0.3213,"citation_percentile":0.6502424,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1},{"year":2024,"count":22},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S037811192030843X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S037811192030843X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.gene.2020.145174","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33007370","host_type":"repository"}],"fields_of_study":["Genetics and Neurodevelopmental Disorders","Chromosomal and Genetic Variations","Autism Spectrum Disorder Research","Adult","Alleles","Anti-Mullerian Hormone","Ataxia","Female","Follicle Stimulating Hormone","Fragile X Messenger Ribonucleoprotein 1","Fragile X Syndrome","Gene Frequency","Humans","Jordan","Ovarian Reserve","Ovary","Primary Ovarian Insufficiency","Promoter Regions, Genetic","Tremor","Trinucleotide Repeat Expansion","Trinucleotide Repeats","Fragile X Tremor Ataxia Syndrome"],"mesh_terms":["Adult","Alleles","Ataxia","Female","Fragile X Syndrome","Follicle Stimulating Hormone","Gene Frequency","Humans","Jordan","Ovary","Promoter Regions, Genetic","Tremor","Primary Ovarian Insufficiency","Trinucleotide Repeats","Trinucleotide Repeat Expansion","Fragile X Mental Retardation Protein","Fragile X Messenger Ribonucleoprotein 1","Anti-Mullerian Hormone","Ovarian Reserve"],"keywords":["Trinucleotide repeat expansion","FMR1","Biology","Allele","Ovarian reserve","Ataxia","Fragile X syndrome","Fragile x","Genetics","Premature ovarian failure","Internal medicine","Endocrinology","Gene","Infertility","Medicine","Assisted reproductive technology","Poor Ovarian Response","Female Infertility","Cgg Repeats"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T02:45:28.747282Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}