{"doi":"10.1016/j.gene.2014.12.020","title":"NEDD4: The founding member of a family of ubiquitin-protein ligases","abstract":null,"journal":"Gene","year":2015,"id":597346,"datarank":0.7676990718625134,"base_score":5.117993812416755,"endowment":5.117993812416755,"self_citation_contribution":0.7676990718625134,"citation_network_contribution":0.0,"self_endowment_contribution":0.7676990718625134,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":166,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":129092,"name":"Sharad Kumar","orcid":null,"position":1,"is_corresponding":false},{"id":1530344,"name":"Natasha Anne Boase","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"NEDD4: The founding member of a family of ubiquitin-protein ligases","abstract":"Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the patho-physiological significance of this important ubiquitin ligase.","is_dataset_classified":null,"base_score":5.117993812416755,"endowment":5.117993812416755,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25527121","pmcid":"PMC6639052","openalex_id":"https://openalex.org/W2029439166","authors":[],"funders":[{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1020755","title":null},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1059393","title":null},{"funder_name":"NHMRC Senior Principal Research Fellowship","grant_id":"1002863","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM089820","title":null}],"total_grants":4,"fwci":3.7692,"citation_percentile":0.94245211,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":11},{"year":2017,"count":15},{"year":2018,"count":11},{"year":2019,"count":17},{"year":2020,"count":16},{"year":2021,"count":22},{"year":2022,"count":17},{"year":2023,"count":18},{"year":2024,"count":25},{"year":2025,"count":8},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0378111914014164?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0378111914014164?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.gene.2014.12.020","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25527121","host_type":"repository"},{"url":"http://hdl.handle.net/2440/106385","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6639052","host_type":"repository"}],"fields_of_study":["Ubiquitin and proteasome pathways","Cancer-related gene regulation","Glycosylation and Glycoproteins Research","Animals","Endosomal Sorting Complexes Required for Transport","Humans","Nedd4 Ubiquitin Protein Ligases","Neoplasms","Oxidative Stress","PTEN Phosphohydrolase","Signal Transduction","Ubiquitin-Protein Ligases","Ubiquitinated Proteins","Ubiquitination"],"mesh_terms":["Nedd4 Ubiquitin Protein Ligases","Animals","Humans","Neoplasms","Signal Transduction","Oxidative Stress","Ubiquitin-Protein Ligases","PTEN Phosphohydrolase","Ubiquitination","Endosomal Sorting Complexes Required for Transport","Ubiquitinated Proteins"],"keywords":["NEDD4","Ubiquitin ligase","Ubiquitin","Biology","Endocytic cycle","Ubiquitin-Protein Ligases","Cell biology","Genetics","Receptor","Endocytosis","Gene","PTEN","Ubiquitin Protein Ligases","Nedd4 Family","Igf Signalling"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"hgnc"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:59:42.401011Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}