{"doi":"10.1016/j.gene.2013.05.041","title":"The HMGB1–TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis","abstract":null,"journal":"Gene","year":2013,"id":658415,"datarank":0.7454719949364003,"base_score":4.969813299576001,"endowment":4.969813299576001,"self_citation_contribution":0.7454719949364003,"citation_network_contribution":0.0,"self_endowment_contribution":0.7454719949364003,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":143,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":291088,"name":"Jun Yang","orcid":"0000-0001-8126-1728","position":1,"is_corresponding":false},{"id":175081,"name":"Ping Chen","orcid":null,"position":2,"is_corresponding":false},{"id":897208,"name":"Jian Yang","orcid":"0000-0003-3281-8803","position":3,"is_corresponding":false},{"id":1718781,"name":"Sun-Qing Bo","orcid":null,"position":4,"is_corresponding":false},{"id":1718783,"name":"Jia-Wang Ding","orcid":null,"position":5,"is_corresponding":false},{"id":1718785,"name":"Qin-Qin Yu","orcid":null,"position":6,"is_corresponding":false},{"id":1718779,"name":"Hua-Sheng Ding","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The HMGB1–TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis","abstract":"Toll-like receptor 4 (TLR4) and its ligand high mobility group box 1 (HMGB1), are known for playing central roles in ischemia-reperfusion injury in myocardium. However, the detailed mechanisms of TLR4 and HMGB1 are not fully understood. The aim of this study was to investigate the effects and possible mechanisms of the HMGB1-TLR4 axis and cardiomyocyte apoptosis on myocardial ischemic damage. Artificial oxygen ventilated anesthetized C3H/HeN mice and C3H/HeJ mice were subjected to 30 min of left anterior descending coronary artery occlusion followed by 6h of reperfusion. The myocardial infarct size, HMGB1 levels, apoptosis index, Bax, Bcl-2 and TNF-α mRNA levels were assessed. The results showed that a lowered amount of cardiomyocyte apoptosis and infarct size in the myocardium of TLR4-mutant mice after myocardial I/R and that TLR4 deficiency notably inhibited the expression of HMGB1 and TNF-a, both of which were up-regulated by ischemia/reperfusion. These findings suggest that the HMGB1-TLR4 axis plays a pathogenic role in triggering cardiomyocyte apoptosis during myocardial I/R injury and that the possible mechanism for this process is the result of released cytokines and inflammatory response involved in the HMGB1/TLR4-related pathway.","is_dataset_classified":null,"base_score":4.969813299576001,"endowment":4.969813299576001,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23727604","pmcid":null,"openalex_id":"https://openalex.org/W1977994316","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81170133","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81200088","title":null},{"funder_name":"Research Project Foundation of China Hubei Province Health Department","grant_id":"JX5B44","title":null}],"total_grants":3,"fwci":7.8195,"citation_percentile":0.98167331,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":9},{"year":2015,"count":20},{"year":2016,"count":14},{"year":2017,"count":13},{"year":2018,"count":10},{"year":2019,"count":15},{"year":2020,"count":10},{"year":2021,"count":11},{"year":2022,"count":11},{"year":2023,"count":8},{"year":2024,"count":10},{"year":2025,"count":5},{"year":2026,"count":5}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S037811191300677X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S037811191300677X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.gene.2013.05.041","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23727604","host_type":"repository"}],"fields_of_study":["Advanced Glycation End Products research","Cardiac Ischemia and Reperfusion","Immune Response and Inflammation","Animals","Apoptosis","Gene Expression","HMGB1 Protein","Male","Mice","Mice, Inbred C3H","Myocardial Reperfusion Injury","Myocytes, Cardiac","Proto-Oncogene Proteins c-bcl-2","Toll-Like Receptor 4","Tumor Necrosis Factor-alpha","bcl-2-Associated X Protein"],"mesh_terms":["Animals","Male","Mice, Inbred C3H","Tumor Necrosis Factor-alpha","Myocardial Reperfusion Injury","Gene Expression","Apoptosis","Proto-Oncogene Proteins c-bcl-2","HMGB1 Protein","Myocytes, Cardiac","bcl-2-Associated X Protein","Toll-Like Receptor 4","Mice"],"keywords":["HMGB1","TLR4","Apoptosis","Biology","Ischemia","Reperfusion injury","Receptor","Inflammation","Internal medicine","Pharmacology","Immunology","Medicine","Biochemistry","Polymerase chain reaction","PCR","Acute myocardial infarction","Ischemia/reperfusion","AMI","Toll-like receptor 4","NF-κB","TNF-α","Nuclear factor kappa B","Apoptosis index","Tumor necrosis factor-α","AI","Anova","I/r","Lad","Rage","Enhanced Chemiluminescence","Receptor For Advanced Glycation End Products","High Mobility Group Box 1","Ecl","Left Anterior Descending Coronary Artery","Aar","Jnks","C-jun N-terminal Kinases","One-way Analysis Of Variance","Myocardial Ischemia/reperfusion Injury","The Area At Risk"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T04:10:05.249472Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}