{"doi":"10.1016/j.gde.2004.06.012","title":"Models for the generation of the embryonic body axes: ontogenetic and evolutionary aspects","abstract":null,"journal":"Current Opinion in Genetics & Development","year":2004,"id":655638,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1711526,"name":"Hans Meinhardt","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Models for the generation of the embryonic body axes: ontogenetic and evolutionary aspects","abstract":"Coelenterates including hydra are assumed to be close to the last common ancestor before bilaterality evolved. Models based on local self-enhancement and long-range inhibition account for pattern formation and regeneration along this ancestral axis. The body of a hydra-like ancestor evolved into the brain and heart of higher organisms, accounting for the close relationship of both patterning processes. Bilateria require a long-extended organizing region to pattern their dorsoventral axis. Models reveal the difficulties in the generation of such a stripe-like organizer and account for different mechanisms realized in vertebrates and insects. Common pathways involved in hydra budding and in the formation of appendages in higher organisms suggest a possible link.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15261663","pmcid":null,"openalex_id":"https://openalex.org/W2010168826","authors":[],"funders":[],"total_grants":0,"fwci":4.8365,"citation_percentile":0.94645525,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2018,"count":2},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0959437X04000917?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0959437X04000917?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.gde.2004.06.012","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15261663","host_type":"repository"}],"fields_of_study":["Marine Invertebrate Physiology and Ecology","Marine Ecology and Invasive Species","Planarian Biology and Electrostimulation"],"mesh_terms":["Animals","Biological Evolution","Hydra","Models, Biological","Signal Transduction","Cell Polarity","Gene Expression Regulation, Developmental","Body Patterning","Embryonic Development"],"keywords":["Lernaean Hydra","Bilateria","Biology","Ancestor","Evolutionary biology","Most recent common ancestor","Appendage","Budding","Evolutionary developmental biology","Biological evolution","Evolution of mammals","Phylogenetics","Anatomy","Genetics","Cell biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T18:23:31.498391Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}