{"doi":"10.1016/j.gastha.2023.08.005","title":"Defining and Phenotyping Gastric Abnormalities in Long-Term Type 1 Diabetes Using a Novel Body Surface Gastric Mapping Device","abstract":"Background and Aims Diabetic gastroenteropathy is associated with poor glycemic control and morbidity in people with type 1 diabetes (T1D). There is a lack of noninvasive techniques to assess and monitor gastric abnormalities. We aimed to define phenotypes of gastric myoelectrical abnormalities in people with longstanding T1D with and without symptoms using a novel noninvasive body surface gastric mapping (BSGM) device. Methods BSGM was performed on people with T1D of >10 years duration and matched controls, employing Gastric Alimetry (Alimetry, New Zealand), comprising of a high-resolution 64-channel array, validated symptom-logging App, and wearable reader. Results Thirty-two people with T1D were recruited (15 with a high symptom burden), and 32 controls. Those with symptoms showed more unstable gastric myoelectrical activity (Gastric Alimetry Rhythm Index 0.39 vs 0.51, P = .017; and lower average spatial covariance 0.48 vs 0.51, P = .009) compared with controls. Symptomatic patients also had a higher prevalence of peripheral neuropathy (67% vs 6%, P = .001), anxiety/depression diagnoses (27% vs 0%, P = .001), and higher mean hemoglobin A1C levels (76 vs 56 mmol/mol, P < .001). BSGM defined distinct phenotypes in T1D participants including those with markedly unstable gastric rhythms (4/32, 12.5%) and abnormally high gastric frequencies (9/32, 28%). Deviation in gastric frequency was positively correlated with symptoms of bloating, upper gut pain, nausea and vomiting, and fullness (R > 0.35, P < .05). Conclusion Gastric symptoms in people with longstanding T1D correlate with myoelectrical abnormalities on BSGM evaluation, in addition to glycemic control, psychological comorbidities, and peripheral neuropathy. BSGM using Gastric Alimetry identified a range of myoelectrical phenotypes, presenting targets for diagnosis, monitoring, and therapy.","journal":"Gastro Hep Advances","year":2023,"id":325891,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9603,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":983599,"name":"Armen A. Gharibans","orcid":"0000-0002-9139-4740","position":1,"is_corresponding":false},{"id":983593,"name":"Stefan Calder","orcid":"0000-0002-5855-1732","position":2,"is_corresponding":false},{"id":449383,"name":"Gabriel Schamberg","orcid":"0000-0002-4188-9614","position":3,"is_corresponding":false},{"id":985239,"name":"Anthony Walters","orcid":"0000-0002-9129-6024","position":4,"is_corresponding":false},{"id":985888,"name":"Jia Jang","orcid":null,"position":5,"is_corresponding":false},{"id":983592,"name":"Chris Varghese","orcid":"0000-0001-7369-8639","position":6,"is_corresponding":false},{"id":985889,"name":"D A Carson","orcid":null,"position":7,"is_corresponding":false},{"id":983597,"name":"Charlotte Daker","orcid":"0000-0001-5218-5973","position":8,"is_corresponding":false},{"id":983594,"name":"Stephen Waite","orcid":"0000-0002-2856-0566","position":9,"is_corresponding":false},{"id":983598,"name":"Christopher N. Andrews","orcid":"0000-0002-2869-4396","position":10,"is_corresponding":false},{"id":985240,"name":"Tim Cundy","orcid":"0000-0003-4890-9400","position":11,"is_corresponding":false},{"id":717991,"name":"Gregory O’Grady","orcid":"0000-0002-5998-1080","position":12,"is_corresponding":false},{"id":778521,"name":"William Xu","orcid":"0000-0002-1270-2769","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:08:28.266998Z","pmid":"39131562","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}