{"doi":"10.1016/j.fsi.2022.07.027","title":"A compound ginseng stem leaf saponins and aluminium adjuvant enhances the potency of inactivated Aeromonas salmonicida vaccine in turbot","abstract":null,"journal":"Fish &amp; Shellfish Immunology","year":2022,"id":613195,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":423632,"name":"Jie Zhou","orcid":"0000-0001-9309-8630","position":1,"is_corresponding":false},{"id":1579549,"name":"Yuanxing Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":649806,"name":"Qin Liu","orcid":"0000-0003-3063-8593","position":3,"is_corresponding":false},{"id":927009,"name":"Qiyao Wang","orcid":"0000-0002-7494-0869","position":4,"is_corresponding":false},{"id":1286202,"name":"Xiaohong Liu","orcid":"0000-0001-6377-4730","position":5,"is_corresponding":false},{"id":332478,"name":"Fei Sun","orcid":"0000-0002-0870-8375","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A compound ginseng stem leaf saponins and aluminium adjuvant enhances the potency of inactivated Aeromonas salmonicida vaccine in turbot","abstract":"Furunculosis caused by Aeromonas salmonicida in turbot farming is increasingly leading to huge economic losses. In this study, an inactivated vaccine containing a compound adjuvant of ginseng stem leaf saponins and aluminum hydroxide gel (GSLS/Alum) was developed against A. salmonicida and evaluated on turbot. As a result, serum antibody titer in vaccinated group was significantly higher than that in control group and the relative percentage survival (RPS) was up to 75.7%. Comparatively, the RPS of groups that vaccinated with only inactivated vaccine and vaccine containing Alum adjuvant or an oil emulsion Montanide™ ISA 763A were 32.4%, 48.6% and 64.9%, respectively. Although the vaccine containing oil adjuvant elicited comparable IgM level as that containing the compound GSLS/Alum adjuvant, the latter had no obvious side effects. Moreover, the inactivated vaccine containing the compound adjuvant was more likely to induce a higher cellular immune response according to the expressions of some immune related genes. Most importantly, an excellent protection of the vaccine containing GSLS/Alum adjuvant was obtained when turbots were naturally infected under clinical condition. In summary, our study demonstrated that the formulation of GSLS and Alum is a potential compound adjuvant in turbot vaccine development.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35843529","pmcid":null,"openalex_id":"https://openalex.org/W4285404846","authors":[],"funders":[{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"CARS-47","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"222201221722","title":null},{"funder_name":"Natural Science Foundation of Shanghai","grant_id":"21ZR1417300","title":null},{"funder_name":"Ministry of Agriculture of the People&apos;s Republic of China","grant_id":"","title":null}],"total_grants":4,"fwci":1.1752,"citation_percentile":0.77222075,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":7},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1050464822004168?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1050464822004168?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.fsi.2022.07.027","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35843529","host_type":"repository"}],"fields_of_study":["Ginseng Biological Effects and Applications","Immune Cell Function and Interaction","Aquaculture disease management and microbiota"],"mesh_terms":["Adjuvants, Immunologic","Alum Compounds","Aluminum","Aluminum Hydroxide","Animals","Emulsions","Flatfishes","Panax","Immunoglobulin M","Saponins","Vaccines, Inactivated","Plant Leaves","Aeromonas salmonicida"],"keywords":["Adjuvant","Alum","Aeromonas salmonicida","Inactivated vaccine","Biology","Turbot","Microbiology","Immune system","Vaccination","Virology","Immunology","Fish <Actinopterygii>","Chemistry","Fishery","Gsls"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T07:02:16.607821Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}