{"doi":"10.1016/j.fshw.2023.03.033","title":"The role of cholesterol in modifying the lipid-lowering effects of Fuzhuan brick-tea in Caenorhabditis elegans via SBP-1/SREBP","abstract":"Fuzhuan brick-tea (FZT) has long been consumed for its supposed weight loss and lipid-lowering benefits. In this study, we show that the regulation of fat storage in Caenorhabditis elegans from a water extract of FZT was affected by cholesterol levels. We found that FZT significantly decreased fat storage under normal cholesterol levels or in a cholesterol-free diet, while lipid accumulation was increased for a high cholesterol diet. Moreover, this mechanism may involve the conserved sterol regulatory element-binding protein (SREBP)/mediator-15 (MDT-15) signaling pathway and the nuclear hormone receptor NHR-80. In addition, lipid synthesis-related genes inhibited by FZT were partially affected by a cholesterol-free diet. Thus, our findings suggested that the potential lipid-lowering effects of FZT may depend on the cholesterol level, which may help to improve the consumption of FZT.","journal":"Food Science and Human Wellness","year":2023,"id":361981,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":612883,"name":"Yan Lü","orcid":"0000-0001-7159-879X","position":1,"is_corresponding":false},{"id":1115119,"name":"Dai Shen","orcid":null,"position":2,"is_corresponding":false},{"id":1115120,"name":"Xiangyue Tang","orcid":null,"position":3,"is_corresponding":false},{"id":750321,"name":"Ligui Xiong","orcid":null,"position":4,"is_corresponding":false},{"id":604488,"name":"Zhonghua Liu","orcid":"0000-0003-0000-4565","position":5,"is_corresponding":false},{"id":749474,"name":"Yushun Gong","orcid":"0000-0002-9534-5719","position":6,"is_corresponding":false},{"id":1115118,"name":"Lianyun Pan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:14:15.063476Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}