{"doi":"10.1016/j.fob.2015.08.011","title":"FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy","abstract":"<jats:p>Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function. FHL1 increased the myostatin activity on a SMAD reporter and increased myostatin dependent myotube wasting. In mice, independent expression of myostatin reduced fibre diameter whereas FHL1 increased fibre diameter, both consistent with previously identified effects of these proteins. However, co‐expression of FHL1 and myostatin reduced fibre diameter to a greater extent than myostatin alone. Together, these data suggest that the expression of FHL1 may exacerbate muscle wasting under the appropriate conditions.</jats:p>","journal":"FEBS Open Bio","year":2015,"id":38161,"datarank":1.3903150286874482,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.861360949995024,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.861360949995024,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":29,"citers_with_citation_signal":26,"citers_with_endowment":26,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":189768,"name":"Dede Lori","orcid":null,"position":1,"is_corresponding":false},{"id":189769,"name":"Dominic J. Wells","orcid":null,"position":2,"is_corresponding":false},{"id":189770,"name":"Paul R. Kemp","orcid":null,"position":3,"is_corresponding":false},{"id":189767,"name":"Jen Y. Lee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26504741","pmcid":"PMC4576159","openalex_id":"https://openalex.org/W1944981537","authors":[],"funders":[{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"","title":null},{"funder_name":"Medical Research Council","grant_id":"","title":null}],"total_grants":2,"fwci":0.6023,"citation_percentile":0.6860661,"influential_citations":1,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2020,"count":6},{"year":2021,"count":9},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.fob.2015.08.011","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.fob.2015.08.011","host_type":"GOLD"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.fob.2015.08.011","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.fob.2015.08.011","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.fob.2015.08.011","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1016/j.fob.2015.08.011","host_type":"publisher"},{"url":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.fob.2015.08.011","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.fob.2015.08.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26504741","host_type":"repository"},{"url":"https://doaj.org/article/d37c35f8b7394d23b5a3600e802ebdb4","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4576159","host_type":"repository"},{"url":"https://researchonline.rvc.ac.uk/id/eprint/9803/1/9803.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4576159","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4576159?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Muscle Physiology and Disorders","Nutrition and Health in Aging","GDF15 and Related Biomarkers","Biology","Medicine"],"mesh_terms":[],"keywords":["Myostatin","Growth differentiation factor","SMAD","Endocrinology","Wasting","Skeletal muscle","Internal medicine","Biology","Muscle hypertrophy","Transforming growth factor","Medicine","Bone morphogenetic protein","Genetics","Mouse","Muscle Wasting","Copd, Chronic Obstructive Pulmonary Disease","Fhl1","Fibre Type","Mhc, Myosin Heavy Chain","Pai-1, Plasminogen Activator Inhibitor 1","Tgf-β, Transforming Growth Factor Beta","Ta, Tibialis Anterior","Vegf-c, Vascular Endothelial Growth Factor C","Fhl1, Four And A Half Lim Domain Protein 1","Gdf-15, Growth And Differentiation Factor 15"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.22604452.v1","title":"Additional file 1 of Kampo formula hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang, TJ-41) ameliorates muscle atrophy by modulating atrogenes and AMPK in vivo and in vitro","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22604452","title":"Additional file 1 of Kampo formula hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang, TJ-41) ameliorates muscle atrophy by modulating atrogenes and AMPK in vivo and in vitro","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-11T00:56:43.148226Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}