{"doi":"10.1016/j.febslet.2010.09.014","title":"Coevolution is a short‐distance force at the protein interaction level and correlates with the modular organization of protein networks","abstract":"<jats:p>We investigated what roles coevolution plays in shaping yeast protein interaction network (PIN). We found that the extent of coevolution between two proteins decreases rapidly as their interacting distance on the PIN increases, suggesting coevolutionary constraint is a short‐distance force at the molecular level. We also found that protein–protein interactions (PPIs) with strong coevolution tend to be enriched in interconnected clusters, whereas PPIs with weak coevolution are more frequently present at inter‐cluster region. The findings indicate the close relationship between coevolution and modular organization of PINs, and may provide insights into evolution and modularity of cellular networks.</jats:p>","journal":"FEBS 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Teng","orcid":"0000-0003-4621-826X","position":2,"is_corresponding":false},{"id":76023,"name":"Liwen Niu","orcid":"0000-0003-1217-1782","position":3,"is_corresponding":false},{"id":184895,"name":"Jiarui Wu","orcid":null,"position":4,"is_corresponding":false},{"id":184894,"name":"Zhi Liang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20837013","pmcid":null,"openalex_id":"https://openalex.org/W2151437643","authors":[],"funders":[{"funder_name":"China Postdoctoral Science Foundation","grant_id":"20070420731","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"30900270","title":null},{"funder_name":"National Natural Science Foundation of 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and Genomic Networks","Fungal and yeast genetics research","Protein Structure and Dynamics","Biology","Medicine","Computational Biology","Databases, Protein","Evolution, Molecular","Fungal Proteins","Protein Interaction Domains and Motifs","Protein Interaction Mapping","Saccharomyces cerevisiae Proteins"],"mesh_terms":["Fungal Proteins","Evolution, Molecular","Computational Biology","Protein Interaction Mapping","Saccharomyces cerevisiae Proteins","Databases, Protein","Protein Interaction Domains and Motifs"],"keywords":["Coevolution","Modular design","Evolutionary biology","Biology","Computer science","Computational 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