{"doi":"10.1016/j.febslet.2009.10.038","title":"ER exit sites – Localization and control of COPII vesicle formation","abstract":"<jats:p>The first membrane trafficking step in the biosynthetic secretory pathway, the export of proteins and lipids from the endoplasmic reticulum (ER), is mediated by COPII‐coated vesicles. In mammalian cells, COPII vesicle budding occurs at specialized sites on the ER, the so‐called transitional ER (tER). Here, we discuss aspects of the formation and maintenance of these sites, the mechanisms by which cargo becomes segregated within them, and the propagation of ER exit sites (ERES) during cell division. All of these features are inherently linked to the formation, maintenance and function of the Golgi apparatus underlining the importance of ERES to Golgi function and more widely in terms of intracellular organization and cellular function.</jats:p>","journal":"FEBS Letters","year":2009,"id":16933,"datarank":6.356242049408272,"base_score":5.1298987149230735,"endowment":5.1298987149230735,"self_citation_contribution":0.7694848072384611,"citation_network_contribution":5.586757242169811,"self_endowment_contribution":0.7694848072384611,"citer_contribution":5.586757242169811,"corpus_percentile":null,"corpus_rank":null,"citation_count":168,"citer_count":162,"citers_with_citation_signal":142,"citers_with_endowment":142,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":123065,"name":"David J. Stephens","orcid":null,"position":1,"is_corresponding":false},{"id":123064,"name":"Annika Budnik","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.1298987149230735,"endowment":5.1298987149230735,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19850039","pmcid":null,"openalex_id":"https://openalex.org/W1991942986","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"G117/554","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/E019633/1","title":null},{"funder_name":"Medical Research Council","grant_id":"G117/554(71630)","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"","title":null},{"funder_name":"Medical Research Council","grant_id":"","title":null}],"total_grants":5,"fwci":5.0524,"citation_percentile":0.95678776,"influential_citations":16,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":9},{"year":2014,"count":10},{"year":2015,"count":7},{"year":2016,"count":10},{"year":2017,"count":14},{"year":2018,"count":14},{"year":2019,"count":11},{"year":2020,"count":10},{"year":2021,"count":11},{"year":2022,"count":12},{"year":2023,"count":3},{"year":2024,"count":12},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2009.10.038","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2009.10.038","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2009.10.038","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2009.10.038","host_type":"publisher"},{"url":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2009.10.038","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.febslet.2009.10.038","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19850039","host_type":"repository"},{"url":"https://hdl.handle.net/1983/42dfb787-79d0-4d60-8e10-d8ccef43f0c6","host_type":"repository"},{"url":"https://research-information.bris.ac.uk/en/publications/42dfb787-79d0-4d60-8e10-d8ccef43f0c6","host_type":"repository"}],"fields_of_study":["Cellular transport and secretion","Lipid Membrane Structure and Behavior","Endoplasmic Reticulum Stress and Disease","Chemistry","Medicine","Biology","Animals","COP-Coated Vesicles","Endoplasmic Reticulum","Humans"],"mesh_terms":["Animals","Endoplasmic Reticulum","Humans","COP-Coated Vesicles"],"keywords":["COPII","Endoplasmic reticulum","Golgi apparatus","Cell biology","Vesicle","COPI","Secretory pathway","Budding","Function (biology)","Biology","Secretion","Vesicular Transport Proteins","Chemistry","Intracellular","Biochemistry","Membrane","Endosome"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.25596446.v1","title":"Additional file 1 of A cilia-bound unconventional secretory pathway for Drosophila odorant receptors","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25596446","title":"Additional file 1 of A cilia-bound unconventional secretory pathway for Drosophila odorant receptors","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25596564.v1","title":"Additional file 2 of A cilia-bound unconventional secretory pathway for Drosophila odorant receptors","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25596564","title":"Additional file 2 of A cilia-bound unconventional secretory pathway for Drosophila odorant receptors","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26705808.v1","title":"Additional file 3 of A cilia-bound unconventional secretory pathway for Drosophila odorant receptors","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26705808","title":"Additional file 3 of A cilia-bound unconventional secretory pathway for Drosophila odorant receptors","publisher":"figshare","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T15:13:23.902339Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}