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These results implicate aberrant glycosylation of α‐DG in the pathogenesis of muscular degeneration in this model animal of muscular dystrophy.</jats:p>","journal":"FEBS Letters","year":2005,"id":637812,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1656288,"name":"Martina Blank","orcid":null,"position":1,"is_corresponding":false},{"id":1656289,"name":"Jörn Schröder","orcid":null,"position":2,"is_corresponding":false},{"id":1656290,"name":"Hiroshi Manya","orcid":null,"position":3,"is_corresponding":false},{"id":1656291,"name":"Teruo Shimizu","orcid":null,"position":4,"is_corresponding":false},{"id":365964,"name":"Kevin P. 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Although dystrophic chicken is well established as an animal model of human muscular dystrophy, the pathomechanism leading to muscular degeneration remains unknown. We show here that glycosylation and laminin‐binding activity of α‐dystroglycan (α‐DG) are defective in dystrophic chicken. Extensive glycan structural analysis reveals that Galβ1‐3GalNAc and GalNAc residues are increased while Siaα2‐3Gal structure is reduced in α‐DG of dystrophic chicken. These results implicate aberrant glycosylation of α‐DG in the pathogenesis of muscular degeneration in this model animal of muscular dystrophy.</jats:p>","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15848172","pmcid":null,"openalex_id":"https://openalex.org/W2127823656","authors":[],"funders":[],"total_grants":0,"fwci":1.0678,"citation_percentile":0.74966528,"influential_citations":0,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":4},{"year":2015,"count":2},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2005.03.033","host_type":"publisher"},{"url":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2005.03.033","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.febslet.2005.03.033","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15848172","host_type":"repository"},{"url":"https://teikyo-u.repo.nii.ac.jp/records/2020930","host_type":"repository"}],"fields_of_study":["Muscle Physiology and Disorders","Silk-based biomaterials and applications","Calpain Protease Function and Regulation"],"mesh_terms":["Animals","Chickens","Chromatography, Affinity","Disease Models, Animal","Glycosylation","Laminin","Muscular Dystrophy, Animal","Protein Binding","Muscle, Skeletal","Plant Lectins","Dystroglycans"],"keywords":["Dystroglycan","Laminin","Muscular dystrophy","ITGA7","Extracellular matrix","Glycoprotein","Congenital muscular dystrophy","Glycosylation","Skeletal muscle","Dystrophin","Biology","Duchenne muscular dystrophy","Cell biology","Molecular biology","Biochemistry","Genetics","Endocrinology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T19:34:19.076388Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}