{"doi":"10.1016/j.fct.2019.110781","title":"Protective effects of raspberry on the oxidative damage in HepG2 cells through Keap1/Nrf2-dependent signaling pathway","abstract":null,"journal":"Food and Chemical Toxicology","year":2019,"id":623958,"datarank":2.304274341055078,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":1.7115877832678636,"self_endowment_contribution":0.5926865577872142,"citer_contribution":1.7115877832678636,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":50,"citers_with_citation_signal":42,"citers_with_endowment":42,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":999214,"name":"Kang Li","orcid":"0000-0003-0355-4255","position":1,"is_corresponding":false},{"id":984586,"name":"Qian Liu","orcid":"0000-0003-0804-043X","position":2,"is_corresponding":false},{"id":1612840,"name":"José L. 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We established a model of oxidative stress in HepG2 cells induced by H<sub>2</sub>O<sub>2</sub> and examined the protein expression of Keap1/Nrf2. The antioxidant activity of raspberry extract was carried out measuring the level of reactive oxygen species (ROS), and the changes of phase II detoxification elements such as GSH level and CAT activity. Also the expression of proteins related to the Keap1/Nrf2 signaling was tested. The results revealed that raspberry extract significantly reduced the ROS levels in oxidative injured cells, increased GSH content and CAT activity, and activated the expression of proteins Keap1, Nrf2, HO-1, NQO1, and γ-GCS. These results taken together indicated that raspberry treatment could ameliorate H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in HepG2 cells via Keap1/Nrf2 pathway.","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31465820","pmcid":null,"openalex_id":"https://openalex.org/W2970433188","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"","title":null}],"total_grants":1,"fwci":2.0496,"citation_percentile":0.87805695,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":10},{"year":2021,"count":9},{"year":2022,"count":7},{"year":2023,"count":12},{"year":2024,"count":6},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S027869151930571X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S027869151930571X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.fct.2019.110781","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31465820","host_type":"repository"}],"fields_of_study":["Genomics, phytochemicals, and oxidative stress","Phytochemicals and Antioxidant Activities","Free Radicals and Antioxidants","Anthocyanins","Antioxidants","Fruit","Glucosides","Hep G2 Cells","Humans","Hydrogen Peroxide","Kelch-Like ECH-Associated Protein 1","NF-E2-Related Factor 2","Oxidative Stress","Plant Extracts","Rubus","Signal Transduction"],"mesh_terms":["Kelch-Like ECH-Associated Protein 1","Anthocyanins","Antioxidants","Fruit","Glucosides","Humans","Hydrogen Peroxide","Plant Extracts","Signal Transduction","Oxidative Stress","NF-E2-Related Factor 2","Hep G2 Cells","Rubus"],"keywords":["KEAP1","Oxidative stress","Reactive oxygen species","Blowing a raspberry","Oxidative phosphorylation","Glutathione","Antioxidant","Chemistry","Signal transduction","Biochemistry","Cell biology","Biology","Enzyme","Food science","Transcription factor","Oxidative damage","HepG2 cells","Raspberry","Cyanidin 3-O-glucoside","Keap1/nrf2 Pathway"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T02:07:23.892661Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}