{"doi":"10.1016/j.exppara.2021.108170","title":"Prospects for liver fluke vaccines","abstract":null,"journal":"Experimental Parasitology","year":2021,"id":680149,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311461,"name":"Ying Sun","orcid":"0000-0002-3027-7727","position":1,"is_corresponding":false},{"id":1777057,"name":"Jingtong Zheng","orcid":"0000-0003-4615-3734","position":2,"is_corresponding":false},{"id":500806,"name":"Jing Zhang","orcid":"0000-0002-4823-4629","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Prospects for liver fluke vaccines","abstract":"Fasciola spp., Opisthorchis spp. and Clonorchis sinensis are common liver flukes that can cause a variety of diseases, mainly cholangiocarcinoma induced by clonorchiasis and liver damage and associated pathology induced by fascioliasis. Because these trematodes are parasites of humans and domestic animals, they have greatly affected the economy of agricultural industries and public health worldwide. Due to the emergence of drug resistance and the living habits of flukes, among other reasons, a possibility of reinfection remains even when antiparasitic drugs are used. Therefore, developing a safe, efficient and cost-effective vaccine against trematodes is an important goal. Here, we briefly describe the progress in the development of vaccines against liver flukes. Related innovations may provide effective protection against these helminths and the diseases that they cause.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34699916","pmcid":null,"openalex_id":"https://openalex.org/W3208727778","authors":[],"funders":[{"funder_name":"Jilin University","grant_id":"2020-31","title":null},{"funder_name":"Jilin University","grant_id":"2021","title":null},{"funder_name":"Jilin Province People's Government Department of Education","grant_id":"JJKH20201026KJ","title":null}],"total_grants":3,"fwci":1.033,"citation_percentile":0.72487108,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0014489421001077/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0014489421001077/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014489421001077?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014489421001077?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.exppara.2021.108170","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34699916","host_type":"repository"}],"fields_of_study":["Parasites and Host Interactions","Helminth infection and control","Parasite Biology and Host Interactions"],"mesh_terms":["Animals","Cattle","Clonorchiasis","Clonorchis sinensis","Fasciola hepatica","Fascioliasis","Humans","Liver Diseases, Parasitic","Opisthorchiasis","Opisthorchis","Rabbits","Sheep","Vaccines"],"keywords":["Clonorchis sinensis","Liver fluke","Clonorchiasis","Fasciolosis","Opisthorchis viverrini","Biology","Fasciola hepatica","Fasciola","Antiparasitic agent","Opisthorchis","Helminths","Helminthiasis","Trematoda","Immunology","Pharmacology","Fasciola Spp.","Opisthorchis Spp."],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T14:29:49.474233Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}