{"doi":"10.1016/j.exppara.2009.09.005","title":"Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole","abstract":null,"journal":"Experimental Parasitology","year":2010,"id":644703,"datarank":1.6921243622199555,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":1.1676482279999836,"self_endowment_contribution":0.5244761342199721,"citer_contribution":1.1676482279999836,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":23,"citers_with_citation_signal":21,"citers_with_endowment":21,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1678224,"name":"Mario Faúndez","orcid":null,"position":1,"is_corresponding":false},{"id":1678225,"name":"Sebastián Klein","orcid":null,"position":2,"is_corresponding":false},{"id":1678227,"name":"Sebastián Escanilla","orcid":null,"position":3,"is_corresponding":false},{"id":697157,"name":"Gloria Torres","orcid":null,"position":4,"is_corresponding":false},{"id":1509863,"name":"Dasfne Lee-Liu","orcid":null,"position":5,"is_corresponding":false},{"id":780762,"name":"Jorge Ferreira","orcid":"0000-0002-5592-6199","position":6,"is_corresponding":false},{"id":730261,"name":"Ulrike Kemmerling","orcid":"0000-0002-0201-1665","position":7,"is_corresponding":false},{"id":1678236,"name":"Myriam Orellana","orcid":null,"position":8,"is_corresponding":false},{"id":1678238,"name":"Antonio Morello","orcid":null,"position":9,"is_corresponding":false},{"id":125857,"name":"Arturo Ferreira","orcid":null,"position":10,"is_corresponding":false},{"id":1678242,"name":"Juan D. 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However, isobolographic analysis of the combined effects of aspirin, nifurtimox and benznidazole indicated a synergistic effect on T. cruzi infection of RAW cells, with combinatory indexes of 0.71 and 0.61, respectively. The observed effect of aspirin upon T. cruzi infection was not related with the PGE(2) synthesis inhibition. Nevertheless, NO() levels were restored by aspirin in T. cruzi-infected RAW cells, contributing to macrophage antiparasitic activity improvement. Thus, the synergy of aspirin with nifurtimox and benznidazole is due to the capability of aspirin to increase antiparasitic activity of macrophages.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19735656","pmcid":null,"openalex_id":"https://openalex.org/W2027584864","authors":[],"funders":[],"total_grants":0,"fwci":1.0866,"citation_percentile":0.78272027,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":3},{"year":2014,"count":4},{"year":2015,"count":3},{"year":2017,"count":5},{"year":2018,"count":3},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3229488","host_type":"repository"},{"url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3229488","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0014489409002604?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014489409002604?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.exppara.2009.09.005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19735656","host_type":"repository"},{"url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3229489","host_type":"repository"},{"url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3229490","host_type":"repository"},{"url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3229491","host_type":"repository"},{"url":"http://hdl.handle.net/10533/141428","host_type":"repository"},{"url":"http://hdl.handle.net/10533/141429","host_type":"repository"},{"url":"http://hdl.handle.net/10533/141430","host_type":"repository"},{"url":"http://hdl.handle.net/10533/141431","host_type":"repository"},{"url":"https://repositorio.uchile.cl/handle/2250/128710","host_type":"repository"}],"fields_of_study":["Trypanosoma species research and implications","Research on Leishmaniasis Studies","Synthesis and Biological Evaluation","Animals","Aspirin","Cell Line","Cell Survival","Cyclooxygenase Inhibitors","Drug Synergism","Inhibitory Concentration 50","Macrophages","Mice","Nifurtimox","Nitric Oxide","Nitroimidazoles","Trypanocidal Agents","Trypanosoma cruzi"],"mesh_terms":["Animals","Aspirin","Cell Line","Cell Survival","Drug Synergism","Macrophages","Nifurtimox","Nitric Oxide","Nitroimidazoles","Trypanocidal Agents","Trypanosoma cruzi","Cyclooxygenase Inhibitors","Inhibitory Concentration 50","Mice"],"keywords":["Benznidazole","Nifurtimox","Trypanosoma cruzi","Antiparasitic","Antiparasitic agent","Pharmacology","Biology","Aspirin","Medicine","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:52:03.224686Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}