{"doi":"10.1016/j.exppara.2003.12.003","title":"Plasmodium chabaudi adami: interferon-γ but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice","abstract":null,"journal":"Experimental Parasitology","year":2003,"id":685831,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1791817,"name":"James M Burns","orcid":null,"position":1,"is_corresponding":false},{"id":1791818,"name":"Francine K Cigel","orcid":null,"position":2,"is_corresponding":false},{"id":1791819,"name":"Heather Lieberg","orcid":null,"position":3,"is_corresponding":false},{"id":1791821,"name":"Dean D Manning","orcid":null,"position":4,"is_corresponding":false},{"id":1791823,"name":"Barbara J Pepper","orcid":null,"position":5,"is_corresponding":false},{"id":1791825,"name":"Deborah M Yañez","orcid":null,"position":6,"is_corresponding":false},{"id":1471685,"name":"Henri van der Heyde","orcid":null,"position":7,"is_corresponding":false},{"id":1791826,"name":"William P Weidanz","orcid":null,"position":8,"is_corresponding":false},{"id":1791816,"name":"Joan M Batchelder","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Plasmodium chabaudi adami: interferon-γ but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice","abstract":"Cell-mediated immunity (CMI) may be important in immunity against blood-stage malaria. Accordingly, we examined the role of type 1 cytokines in the resolution of Plasmodium chabaudi adami malaria in mice genetically modified to have type 1 cytokine gene defects. Parasitemia was prolonged in double knockout (IL-2(-/-), IFNgamma(-/-)) mice compared to control mice. Despite deficiencies in gammadelta T cell and B cell subsets, these mice produced anti-malarial antibodies and eventually cured their infections, possibly by antibody-mediated immunity. However, because acute P. c. adami parasitemia may also be suppressed by CMI, the requirements for IL-2 and IFNgamma were evaluated in mice lacking B cells and functional IL-2 or IFNgamma genes. Acute malaria in J(H)(-/-), IL-2(-/-) mice was prolonged, but eventually cured. In contrast, J(H)(-/-), IFNgamma(-/-) mice developed unremitting parasitemia. These data strongly suggest that IFNgamma, but not IL-2, plays an essential role in the expression of CMI against P. c. adami infections. This finding may prove useful in developing malarial vaccines aimed at inducing CMI.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14969693","pmcid":null,"openalex_id":"https://openalex.org/W2042130302","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI 49585","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI 12710","title":null}],"total_grants":2,"fwci":1.4015,"citation_percentile":0.82654119,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2016,"count":1},{"year":2020,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014489403001759?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014489403001759?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.exppara.2003.12.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/14969693","host_type":"repository"}],"fields_of_study":["Malaria Research and Control","Parasites and Host Interactions","Complement system in diseases","Animals","Antibodies, Protozoan","Enzyme-Linked Immunosorbent Assay","Female","Flow Cytometry","Immunity, Cellular","Immunoglobulin G","Immunoglobulin M","Interferon-gamma","Interleukin-2","Lymphocyte Subsets","Malaria","Male","Mice","Mice, Knockout","Parasitemia","Plasmodium chabaudi","Spleen"],"mesh_terms":["Animals","Antibodies, Protozoan","Enzyme-Linked Immunosorbent Assay","Female","Flow Cytometry","Immunoglobulin G","Immunoglobulin M","Immunity, Cellular","Interferon-gamma","Interleukin-2","Malaria","Male","Spleen","Lymphocyte Subsets","Plasmodium chabaudi","Mice, Knockout","Parasitemia","Mice"],"keywords":["Plasmodium chabaudi","Parasitemia","Biology","Immunity","Immunology","Malaria","Antibody","Cytokine","Interferon gamma","T cell","Acquired immune system","Virology","Immune system","Plasmodium falciparum"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T17:46:46.953966Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}