{"doi":"10.1016/j.expneurol.2010.08.006","title":"Increased subventricular zone-derived cortical neurogenesis after ischemic lesion","abstract":null,"journal":"Experimental Neurology","year":2010,"id":593392,"datarank":0.6937459219926407,"base_score":4.624972813284271,"endowment":4.624972813284271,"self_citation_contribution":0.6937459219926407,"citation_network_contribution":0.0,"self_endowment_contribution":0.6937459219926407,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":101,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1120456,"name":"Evgeny Kanov","orcid":null,"position":1,"is_corresponding":false},{"id":1518714,"name":"Oleg Timofeev","orcid":null,"position":2,"is_corresponding":false},{"id":297380,"name":"Markus Schwaninger","orcid":"0000-0002-4510-9718","position":3,"is_corresponding":false},{"id":224982,"name":"Hannah Monyer","orcid":null,"position":4,"is_corresponding":false},{"id":241520,"name":"Konstantin Khodosevich","orcid":"0000-0001-7232-5558","position":5,"is_corresponding":false},{"id":1518713,"name":"Maria Kreuzberg","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Increased subventricular zone-derived cortical neurogenesis after ischemic lesion","abstract":"In adult rodents stroke enhances neurogenesis resulting in the addition of neurons to forebrain regions such as striatum or cortex where postnatal neurogenesis under normal conditions plays a negligible role. In the cortex, new neurons are generated either from local cortical precursors that are activated by stroke or from precursors residing in the subventricular zone (SVZ) of lateral ventricles that under normal conditions supply neuroblasts by and large only for the olfactory bulb. In this study we used 5HT3A-EGFP transgenic mice in which all neuroblasts originating in the SVZ are EGFP-labeled. We induced stroke in these mice and by combination of EGFP detection with BrdU injections we labeled all post-stroke-generated SVZ-derived neuroblasts. We showed an increase in SVZ-derived neuroblasts 14 and 35 days after stroke in the ipsilateral hemisphere. Post-stroke-generated SVZ-derived neuroblasts migrated to the cortex and survived for at least 35 days representing 2% of BrdU-positive cells in peri-infarct area where they differentiate into mature neurons. Thus, stroke enhances SVZ neurogenesis and attracts newborn neurons to the injury zone.","is_dataset_classified":null,"base_score":4.624972813284271,"endowment":4.624972813284271,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20713052","pmcid":null,"openalex_id":"https://openalex.org/W2011723175","authors":[],"funders":[{"funder_name":"European Commission FP7","grant_id":"FP7_202213","title":null},{"funder_name":"European Commission FP7","grant_id":"FP7_201024","title":null},{"funder_name":"European Commission","grant_id":"201024","title":"Affording Recovery In Stroke"},{"funder_name":"European Commission","grant_id":"202213","title":"European Stroke Research Network"}],"total_grants":4,"fwci":3.6188,"citation_percentile":0.92753623,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":12},{"year":2014,"count":8},{"year":2015,"count":4},{"year":2016,"count":8},{"year":2017,"count":9},{"year":2018,"count":2},{"year":2019,"count":5},{"year":2020,"count":9},{"year":2021,"count":8},{"year":2022,"count":6},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"https://zenodo.org/record/3418040","host_type":"repository"},{"url":"https://zenodo.org/record/3418040","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0014488610002888?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014488610002888?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.expneurol.2010.08.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20713052","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.expneurol.2010.08.006","host_type":""},{"url":"https://dx.doi.org/10.1016/j.expneurol.2010.08.006","host_type":""}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Neuroinflammation and Neurodegeneration Mechanisms","Nerve injury and regeneration","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Animals","Antimetabolites","Apoptosis","Brain Ischemia","Bromodeoxyuridine","Calbindin 2","Caspase 3","Cerebral Cortex","Cerebral Ventricles","DNA-Binding Proteins","Green Fluorescent Proteins","Immunohistochemistry","Infarction, Middle Cerebral Artery","Interneurons","Mice","Mice, Transgenic","Nerve Tissue Proteins","Neurogenesis","Neurons","Nuclear Proteins","Prefrontal Cortex","Receptors, Serotonin, 5-HT3","S100 Calcium Binding Protein G","gamma-Aminobutyric Acid"],"mesh_terms":["Animals","Antimetabolites","Bromodeoxyuridine","Cerebral Cortex","Brain Ischemia","Cerebral Ventricles","DNA-Binding Proteins","gamma-Aminobutyric Acid","Immunohistochemistry","Interneurons","Mice, Transgenic","Nerve Tissue Proteins","Neurons","Nuclear Proteins","Apoptosis","Prefrontal Cortex","Infarction, Middle Cerebral Artery","Receptors, Serotonin, 5-HT3","Green Fluorescent Proteins","Mice","Caspase 3","Neurogenesis","S100 Calcium Binding Protein G","Calbindin 2"],"keywords":["Neuroblast","Neurogenesis","Subventricular zone","Olfactory bulb","Neuroscience","Neural stem cell","Rostral migratory stream","Lateral ventricles","Cortex (anatomy)","Biology","Cerebral cortex","Stroke (engine)","Anatomy","Cell biology","Central nervous system","Stem cell","Neurons","Antimetabolites","Caspase 3","Green Fluorescent Proteins","Nuclear Proteins","Apoptosis","Infarction, Middle Cerebral Artery","Mice, Transgenic","Nerve Tissue Proteins","Immunohistochemistry","Brain Ischemia","Cerebral Ventricles","DNA-Binding Proteins","Mice","Bromodeoxyuridine","Interneurons","Calbindin 2","Animals"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T10:39:06.618071Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}