{"doi":"10.1016/j.exphem.2024.104621","title":"A-to-I RNA editing and hematopoiesis","abstract":null,"journal":"Experimental Hematology","year":2024,"id":643154,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":75377,"name":"Carl R. Walkley","orcid":"0000-0002-4784-9031","position":1,"is_corresponding":false},{"id":1673291,"name":"Jacki E. Heraud-Farlow","orcid":null,"position":2,"is_corresponding":false},{"id":1161690,"name":"Zhen Liang","orcid":"0000-0003-1487-1555","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A-to-I RNA editing and hematopoiesis","abstract":"Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2, respectively. A-to-I editing by ADAR1 is also critical in regulating hematopoiesis. This review will focus on the role of A-to-I RNA editing and ADAR enzymes, particularly ADAR1, during normal hematopoiesis in humans and mice. Furthermore, we will discuss Adar1 mouse models that have been developed to understand the contribution of ADAR1 to hematopoiesis and its role in innate immune pathways.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39187172","pmcid":null,"openalex_id":"https://openalex.org/W4401865486","authors":[],"funders":[],"total_grants":0,"fwci":1.7633,"citation_percentile":0.84904309,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":6}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.exphem.org/article/S0301472X24004855/pdf","host_type":"journal"},{"url":"http://www.exphem.org/article/S0301472X24004855/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0301472X24004855?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0301472X24004855?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.exphem.2024.104621","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39187172","host_type":"repository"}],"fields_of_study":["RNA regulation and disease","interferon and immune responses","RNA Research and Splicing","RNA Editing","Hematopoiesis","Animals","Adenosine Deaminase","Humans","Adenosine","Inosine","RNA-Binding Proteins","Mice","Immunity, Innate"],"mesh_terms":["Adenosine","Adenosine Deaminase","Animals","Hematopoiesis","Humans","Immunity, Innate","Inosine","RNA-Binding Proteins","RNA Editing","Mice"],"keywords":["RNA editing","Haematopoiesis","RNA","Computational biology","Computer science","Biology","Cell biology","Genetics","Stem cell","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T13:20:16.581156Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}