{"doi":"10.1016/j.exer.2021.108441","title":"Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion","abstract":null,"journal":"Experimental Eye Research","year":2021,"id":659662,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1721995,"name":"Anri Nishinaka","orcid":null,"position":1,"is_corresponding":false},{"id":1101598,"name":"Takumi Yamamoto","orcid":"0000-0002-9223-5987","position":2,"is_corresponding":false},{"id":585849,"name":"Wataru Otsu","orcid":"0000-0002-5930-1954","position":3,"is_corresponding":false},{"id":585848,"name":"Shinsuke Nakamura","orcid":"0000-0003-2621-6363","position":4,"is_corresponding":false},{"id":585851,"name":"Masamitsu Shimazawa","orcid":"0000-0001-9141-8733","position":5,"is_corresponding":false},{"id":1721997,"name":"Takashi Kitaoka","orcid":null,"position":6,"is_corresponding":false},{"id":585852,"name":"Hideaki Hara","orcid":"0000-0003-2046-9001","position":7,"is_corresponding":false},{"id":1721992,"name":"Sugao Miyagi","orcid":"0000-0001-5374-8213","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion","abstract":"Retinal vein occlusion (RVO) is a vascular disease that represents characteristic retinal hemorrhage and dilated retinal veins. Despite its clinical importance, its pathogenesis remains largely unknown because of limited opportunities to acquire human retinal samples. Therefore, an animal model that reproduces the clinical features of RVO patients is required for further investigation. In this study, we established a pigmented murine RVO model that reproduced characteristic fundus appearances similar to human RVO findings. Retinal edema in this model was observed in both optical coherence tomography and histological analysis, which is a clinically important outcome. With quantitative real-time PCR analysis on retinal samples, we revealed that the mRNA level of vascular endothelial growth factor (VEGF) increased in the retina induced RVO. Moreover, this retinal edema was reduced by intravitreal injection of anti-VEGF antibody. These results were consistent with human clinical knowledge and suggested that this model could be a useful tool for research into new therapeutic approaches.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33453278","pmcid":null,"openalex_id":"https://openalex.org/W3120588516","authors":[],"funders":[],"total_grants":0,"fwci":1.2579,"citation_percentile":0.76734002,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014483521000063?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014483521000063?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.exer.2021.108441","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33453278","host_type":"repository"}],"fields_of_study":["Retinal Diseases and Treatments","Retinal Development and Disorders","Blood Coagulation and Thrombosis Mechanisms"],"mesh_terms":["Animals","Antibodies, Anti-Idiotypic","Disease Models, Animal","Fluorescein Angiography","Humans","Immunoglobulin G","Macular Edema","Male","Mice, Inbred C57BL","Retinal Vein Occlusion","RNA, Messenger","Treatment Outcome","Tomography, Optical Coherence","Vascular Endothelial Growth Factor A","Mice","Real-Time Polymerase Chain Reaction"],"keywords":["Retinal Vein","Retinal","Occlusion","Fundus (uterus)","Retina","Macular edema","Ophthalmology","Medicine","Central retinal vein","Edema","Pathology","Optical coherence tomography","Vascular endothelial growth factor","Vascular occlusion","Anatomy","Biology","VEGF receptors","Internal medicine","Neuroscience","VEGF","Murine model","Retinal Vein Occlusion"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T07:22:13.127659Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}