{"doi":"10.1016/j.euros.2020.06.005","title":"Risk of Recurrent Disease 6 Years After Open or Robotic-assisted Radical Prostatectomy in the Prospective Controlled Trial LAPPRO","abstract":"Conclusive evidence of superiority in oncological outcome for robot-assisted laparoscopic prostatectomy (RALP) over retropubic radical prostatectomy (RRP) is lacking. To compare RALP and RRP regarding recurrent disease and to report the mortality rate 6 yr after surgery. A total of 4003 men with localized prostate cancer were enrolled between 2008 and 2011 in Laparoscopic Prostatectomy Robot Open (LAPPRO)— a prospective, controlled, nonrandomized trial performed at 14 Swedish centers. Data were collected at visits and by patient questionnaires at 3, 12, and 24 mo, and through a structured telephone interview at 6 yr. Cause of death was retrieved from the National Cause of Death Register in Sweden. The modified Poisson regression approach was used for analyses. After adjustment for patient-, tumor-, and surgeon-related confounders, no statistically significant difference was observed between RALP and RRP in biochemical recurrence rate (14 vs 16%, relative risk [RR] 0.77, 95% confidence interval [CI] 0.56–1.06) or in not cured endpoint (22% vs 23%, RR 0.82, 95% CI 0.6–1.11). Stratified by D’Amico risk group, a significant benefit for RALP existed for recurrent disease in high-risk patients (RR 0.47, 95% CI 0.26–0.86, p = 0.02). All-cause mortality was 3% (n = 96). Prostate cancer–specific mortality was 0.6% (n = 21) overall, 0.3% (n = 8) after RALP, and 1.5% (n = 13) after RRP. The nonrandomized design is a limitation. No significant difference was observed for cancer recurrence rate between RALP and RRP 6 yr after surgery. However, in a subgroup analysis, we found a significant benefit for RALP regarding recurrence rate in the high-risk group. Larger studies with longer follow-up are needed to make a firm conclusion and to evaluate a possible survival benefit. In general, the oncological outcome is comparable between robotic and open radical prostatectomy 6 yr after surgery. For high-risk patients, our findings indicate that there is an advantage for robotics, but further studies with longer follow-up time is needed to make a firm conclusion.","journal":"European Urology Open Science","year":2020,"id":88411,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9447,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":447890,"name":"Olof Akre","orcid":"0000-0002-3750-3029","position":1,"is_corresponding":false},{"id":447891,"name":"David Bock","orcid":"0000-0001-9111-9602","position":2,"is_corresponding":false},{"id":253868,"name":"Sigrid Carlsson","orcid":"0000-0003-3553-5710","position":3,"is_corresponding":false},{"id":447892,"name":"Stefan Carlsson","orcid":"0000-0002-8489-5029","position":4,"is_corresponding":false},{"id":350627,"name":"Jonas Hugosson","orcid":"0000-0002-2324-2817","position":5,"is_corresponding":false},{"id":447893,"name":"Anna Lantz","orcid":"0000-0002-5335-8028","position":6,"is_corresponding":false},{"id":447894,"name":"Gunnar Steineck","orcid":"0000-0002-0787-3969","position":7,"is_corresponding":false},{"id":447895,"name":"Johan Stranne","orcid":"0000-0002-4295-6524","position":8,"is_corresponding":false},{"id":447896,"name":"Stavros Ι. Tyritzis","orcid":"0000-0003-1993-0446","position":9,"is_corresponding":false},{"id":447897,"name":"Peter Wiklund","orcid":"0000-0001-6497-4697","position":10,"is_corresponding":false},{"id":448630,"name":"Eva Haglind","orcid":null,"position":11,"is_corresponding":false},{"id":315696,"name":"Anders Bjartell","orcid":"0000-0002-5761-3786","position":12,"is_corresponding":false},{"id":447889,"name":"Martin Nyberg","orcid":"0000-0002-6487-1601","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-18T22:00:56.736935Z","pmid":"34337458","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}