{"doi":"10.1016/j.esmorw.2025.100141","title":"Development and validation of a clinical prediction model for hospitalization after emergency department admission in patients with cancer","abstract":"Background and purpose Emergency department (ED) admissions by cancer patients often result in hospitalization and prolonged ED stays, contributing to overcrowding. Early identification of patients at risk of hospitalization could improve ED flow and ensure timely provision of oncological care. This study aimed to develop and validate models to predict hospitalization among cancer patients admitted to the ED. Methods Adult cancer patients who were admitted to the ED between 1 July 2018 and 30 September 2020 at the Erasmus University Medical Center were included. Data from electronic health records (EHR) were used to develop two logistic regression models: (i) a baseline model including predictors available after ED triage (e.g. patient characteristics, vital parameters) and (ii) an extended model including blood test results. Predictors were selected using the Wald χ 2 statistic. To prevent overfitting, a uniform shrinkage factor was applied. Model performance was assessed with temporal validation (1 October 2019 to 1 January 2020) and evaluated with calibration plots and C-statistics. Results Of 7284 ED admissions, 3967 (54%) resulted in hospitalization. The most common cancers requiring hospitalization were lung, hepatopancreatobiliary, and colorectal cancer. The baseline model included age, sex, primary malignancy, symptoms, metastasis, temperature, pain score, diastolic blood pressure, and heart rate. The model showed good calibration (intercept −0.04, slope 0.86) and discriminative ability [C-statistic 0.71, 95% confidence interval (CI) 0.68-0.74]. The extended model showed improved performance (intercept −0.09, slope 0.92; C-statistic 0.75, 95% CI 0.72-0.78). Conclusion Hospitalization risk of cancer patients admitted to the ED can be predicted using routinely collected EHR data, which could aid in optimizing ED patient flow and ensuring timely provision of oncological services.","journal":"ESMO Real World Data and Digital Oncology","year":2025,"id":565632,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":89354,"name":"David van Klaveren","orcid":"0000-0002-2096-606X","position":1,"is_corresponding":false},{"id":1469255,"name":"Jason G.A. den Duijn","orcid":"0009-0000-6270-9611","position":2,"is_corresponding":false},{"id":1469256,"name":"Rob J.C.G. Verdonschot","orcid":"0000-0003-4124-256X","position":3,"is_corresponding":false},{"id":1469565,"name":"N. Wlazlo","orcid":null,"position":4,"is_corresponding":false},{"id":856382,"name":"Joachim G.J.V. Aerts","orcid":"0000-0001-6662-2951","position":5,"is_corresponding":false},{"id":77474,"name":"Jacoline E. C. Bromberg","orcid":"0000-0002-3830-7142","position":6,"is_corresponding":false},{"id":85616,"name":"Hester F. Lingsma","orcid":"0000-0003-2063-9533","position":7,"is_corresponding":false},{"id":1145939,"name":"Jelmer Alsma","orcid":"0000-0002-2808-1514","position":8,"is_corresponding":false},{"id":1469257,"name":"Monique M.E.M. Bos","orcid":"0000-0002-1913-483X","position":9,"is_corresponding":false},{"id":1469254,"name":"Z Kaplan","orcid":"0000-0003-1620-1811","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:56:32.546082Z","pmid":"41647711","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}