{"doi":"10.1016/j.envres.2025.123165","title":"Household air pollution exposures over pregnancy and maternal blood pressure trajectories through 8 years postpartum: Evidence from the Ghana Randomized Air Pollution and Health Study (GRAPHS)","abstract":"BACKGROUND: Household air pollution is a major contributor to cardiovascular disease burden in women in Sub-Saharan Africa. However, little is known about exposures during pregnancy or the effect of clean cooking interventions on postpartum blood pressure trajectories. METHODS: The Ghana Randomized Air Pollution and Health Study (GRAPHS) randomized 1414 non-smoking women in the first and second trimesters to liquefied petroleum gas (LPG) or improved biomass stoves - vs control (traditional three-stone open fire). Personal exposure to carbon monoxide (CO) was measured at four prenatal timepoints and three times over the first postpartum year. A subset of 690 participants were prospectively followed with annual resting BP measurements at 2, 4, 5, 6, 7, and 8 years postpartum. We employed linear mixed effects models to determine effect of GRAPHS interventions on postpartum BP, and to examine associations between prenatal and postnatal CO and postpartum BP. RESULTS: The LPG intervention was associated with 3.54 mmHg (95 % CI -5.55, -1.53) lower change in systolic BP from enrolment through 8 years postpartum, and 2.27 mmHg (95 % CI -3.61, -0.93) lower change in diastolic BP from enrolment through 8 years postpartum, as compared to control. In exposure-response analysis, average prenatal CO was positively associated with change in systolic BP from enrolment (β = 0.71 mmHg, 95 % CI 0.08, 1.30, per doubling of CO) in pregnant persons carrying male fetuses. CONCLUSIONS: The LPG cookstove intervention initiated in early pregnancy and maintained through the first postpartum year was associated with lower systolic and diastolic BP trajectories through 8 years postpartum. These findings support the need to integrate clean cooking solutions into existing antenatal care packages.","journal":"Environmental Research","year":2025,"id":547799,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9264,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":592132,"name":"Michelle Li","orcid":"0000-0002-9778-984X","position":1,"is_corresponding":false},{"id":420845,"name":"Mohammed Mujtaba","orcid":"0000-0003-4393-5626","position":2,"is_corresponding":false},{"id":291145,"name":"Elena Colicino","orcid":"0000-0002-1875-8448","position":3,"is_corresponding":false},{"id":1440150,"name":"Sule Awuni","orcid":null,"position":4,"is_corresponding":false},{"id":333901,"name":"Blair J. Wylie","orcid":"0000-0003-4818-1050","position":5,"is_corresponding":false},{"id":917870,"name":"Musah Osei","orcid":null,"position":6,"is_corresponding":false},{"id":338334,"name":"Kholiswa Tsotetsi","orcid":null,"position":7,"is_corresponding":false},{"id":1440149,"name":"Tawfiq Yussif","orcid":null,"position":8,"is_corresponding":false},{"id":288767,"name":"Steven N. Chillrud","orcid":"0000-0001-6685-0401","position":9,"is_corresponding":false},{"id":244742,"name":"Darby Jack","orcid":"0000-0002-9932-0201","position":10,"is_corresponding":false},{"id":413940,"name":"Kwaku Poku Asante","orcid":"0000-0001-9158-351X","position":11,"is_corresponding":false},{"id":338910,"name":"Alison Lee","orcid":"0000-0001-5518-5442","position":12,"is_corresponding":false},{"id":581763,"name":"Seyram Kaali","orcid":"0000-0001-6949-4203","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:53:53.962932Z","pmid":"41120010","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}