{"doi":"10.1016/j.envres.2024.119555","title":"Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion","abstract":"BACKGROUND: Evidence suggests that prenatal per- and polyfluoroalkyl substances (PFAS) and metals, two classes of chemicals found ubiquitously in human populations, influence immune system development and response. OBJECTIVE: We evaluated whether first trimester blood PFAS and metals were associated with antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion. METHODS: We measured six PFAS, as well as six nonessential and four essential metals, in first trimester blood from participants in the longitudinal pre-birth Project Viva cohort, recruited between 1999 and 2000 in eastern Massachusetts. We measured antigen- or mitogen-stimulated cord blood mononuclear cell proliferation responses (n = 269-314) and cytokine secretion (n = 217-302). We used covariate-adjusted least absolute shrinkage and selection operator (LASSO) for variable selection and multivariable regression to estimate associations with the immune markers. RESULTS: Each ng/mL of MeFOSAA was associated with a 3.6% (1.4, 5.8) higher lymphocyte proliferation response after stimulation with egg antigen, as well as 0.8 (0.7, 1.0) reduced odds of having IFN-γ detected in response to dust mite. Each ng/g increment of cesium was associated with 27.8% (-45.1, -4.9) lower IL-10 levels in response to dust mite. Each ng/g increment of mercury was associated with 12.0% (1.3, 23.8) higher IL-13 levels in response to mitogen PHA. Each ng/g increment of selenium and zinc was associated with 0.2% (0.01, 0.4) and 0.01% (0.002, 0.02) higher TNF-α in response to mitogen PHA, respectively. CONCLUSIONS: Prenatal metals and PFAS influence cord blood lymphocyte proliferation and cytokine secretion in ways that may increase risk for atopic disease in childhood.","journal":"Environmental Research","year":2024,"id":452249,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":337655,"name":"Pi‐I D. Lin","orcid":"0000-0003-3564-4255","position":1,"is_corresponding":false},{"id":254530,"name":"Sheryl L. Rifas‐Shiman","orcid":"0000-0003-0033-920X","position":2,"is_corresponding":false},{"id":254531,"name":"Abby F. Fleisch","orcid":"0000-0002-2789-6412","position":3,"is_corresponding":false},{"id":54933,"name":"Robert O. Wright","orcid":"0000-0003-1180-6459","position":4,"is_corresponding":false},{"id":94039,"name":"Brent A. Coull","orcid":"0000-0002-1808-4156","position":5,"is_corresponding":false},{"id":424038,"name":"Patricia W. Finn","orcid":"0000-0001-6936-103X","position":6,"is_corresponding":false},{"id":239883,"name":"Emily Oken","orcid":"0000-0003-2513-3339","position":7,"is_corresponding":false},{"id":71916,"name":"Diane R. Gold","orcid":"0000-0001-8789-418X","position":8,"is_corresponding":false},{"id":274134,"name":"Andrés Cárdenas","orcid":"0000-0003-2284-3298","position":9,"is_corresponding":false},{"id":650203,"name":"Anna R. Smith","orcid":"0000-0003-1047-3859","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:02:50.407779Z","pmid":"38964580","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}