{"doi":"10.1016/j.envres.2019.109072","title":"Methylmercury and long chain polyunsaturated fatty acids are associated with immune dysregulation in young adults from the Seychelles child development study.","abstract":"BACKGROUND: Exposure to the environmental toxicant mercury (Hg) has been associated with immune dysregulation, including autoimmune disease, but few human studies have examined methylmercury (MeHg) exposure from fish consumption. OBJECTIVES: We examined associations between MeHg exposure and biological markers of autoimmunity and inflammation while adjusting for long chain polyunsaturated fatty acids (LCPUFA). METHOD: At age 19 years, hair total Hg (Y19Hg), LCPUFA status, a panel of 13 antinuclear antibodies (ANA), total serum immunoglobulins (Ig) IgG, IgA, and IgM and serum markers of inflammation (IL-1, IL-2, IL-6, IL-10, C-reactive protein (CRP), IFN-γ, TNF-α) were measured in the Seychelles Child Development Study (SCDS) Main Cohort (n = 497). Multivariable regression models investigated the association between Y19Hg and biomarkers, adjusting for prenatal total hair Hg (MatHg) and other relevant covariates, and with and without adjustment for LCPUFA. RESULTS: With each 1 ppm increase in Y19Hg (mean 10.23 (SD 6.02) ppm) we observed a 4% increased odds in a positive Combined ANA following adjustment for the n6:n3 LCPUFA ratio (β = 0.036, 95%; CI: 0.001, 0.073). IgM was negatively associated with Y19Hg (β = -0.016, 95%CI: 0.016, -0.002) in models adjusted for n-3, n-6 LCPUFA and when separately adjusted for the n-6:n-3 LCPUFA ratio. No associations were observed with MatHg. Total n-3 LCPUFA status was associated with reduced odds of a positive anti-ribonuclear protein (RNP) A. The n-3 LCPUFA were negatively associated with IL-6, IL-10, CRP, IFN-γ, TNF-α and positively with TNF-α:IL-10. There were positive associations between the n-6:n-3 ratio and IL-6, IL-10, CRP, IFN-γ, TNF-α and a negative association with TNF-α:IL-10. DISCUSSION: The Y19Hg exposure was associated with higher ANA and lower IgM albeit only following adjustment for the n-3 LCPUFA or the n-6:n-3 LCPUFA ratio. The clinical significance of these findings is unclear, but warrant follow up at an older age to determine any relationship to the onset of autoimmune disease.","journal":"Environmental Research","year":2020,"id":107052,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9621,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":333978,"name":"Edwin van Wijngaarden","orcid":"0000-0001-7583-4630","position":1,"is_corresponding":false},{"id":373390,"name":"Alison J. Yeates","orcid":"0000-0002-2393-1663","position":2,"is_corresponding":false},{"id":373386,"name":"Toni Spence","orcid":"0000-0003-2267-2433","position":3,"is_corresponding":false},{"id":373385,"name":"Maria S. Mulhern","orcid":"0000-0002-2212-3744","position":4,"is_corresponding":false},{"id":362693,"name":"Donald Harrington","orcid":null,"position":5,"is_corresponding":false},{"id":361059,"name":"Sally W. Thurston","orcid":"0000-0003-2538-762X","position":6,"is_corresponding":false},{"id":333973,"name":"Tanzy Love","orcid":"0000-0002-7154-0229","position":7,"is_corresponding":false},{"id":513460,"name":"Todd A. Jusko","orcid":"0000-0002-3194-6718","position":8,"is_corresponding":false},{"id":515233,"name":"Philip J. Allsopp","orcid":"0000-0003-1327-162X","position":9,"is_corresponding":false},{"id":373383,"name":"Marie C. Conway","orcid":"0000-0002-3219-7595","position":10,"is_corresponding":false},{"id":335572,"name":"Philip W. Davidson","orcid":null,"position":11,"is_corresponding":false},{"id":333977,"name":"Gary J. Myers","orcid":"0000-0003-4317-015X","position":12,"is_corresponding":false},{"id":304182,"name":"Gene E. Watson","orcid":"0000-0002-3397-1116","position":13,"is_corresponding":false},{"id":335573,"name":"Conrad F. Shamlaye","orcid":null,"position":14,"is_corresponding":false},{"id":333976,"name":"JJ Strain","orcid":"0000-0002-1633-2873","position":15,"is_corresponding":false},{"id":373384,"name":"Emeir M. McSorley","orcid":"0000-0003-1861-3991","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T23:12:31.053776Z","pmid":"32007747","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}