{"doi":"10.1016/j.envpol.2022.119356","title":"A review of practical statistical methods used in epidemiological studies to estimate the health effects of multi-pollutant mixture","abstract":null,"journal":"Environmental Pollution","year":2022,"id":611906,"datarank":0.831189531773764,"base_score":5.541263545158426,"endowment":5.541263545158426,"self_citation_contribution":0.831189531773764,"citation_network_contribution":0.0,"self_endowment_contribution":0.831189531773764,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":254,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":659622,"name":"Wei Liu","orcid":"0000-0002-1587-9316","position":1,"is_corresponding":false},{"id":994443,"name":"Xing Wang","orcid":"0000-0001-5800-9372","position":2,"is_corresponding":false},{"id":1204227,"name":"Zi Ye","orcid":"0000-0002-8963-0521","position":3,"is_corresponding":false},{"id":1575216,"name":"Qiyou Tan","orcid":null,"position":4,"is_corresponding":false},{"id":1410240,"name":"Weihong Qiu","orcid":"0000-0002-0832-5593","position":5,"is_corresponding":false},{"id":1575217,"name":"Xiuquan Nie","orcid":null,"position":6,"is_corresponding":false},{"id":1575219,"name":"Minjing Li","orcid":null,"position":7,"is_corresponding":false},{"id":364819,"name":"Bin Wang","orcid":"0000-0001-9032-5009","position":8,"is_corresponding":false},{"id":695591,"name":"Weihong Chen","orcid":"0000-0001-9205-5399","position":9,"is_corresponding":false},{"id":1575215,"name":"Linling Yu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A review of practical statistical methods used in epidemiological studies to estimate the health effects of multi-pollutant mixture","abstract":"Environmental risk factors have been implicated in adverse health effects. Previous epidemiological studies on environmental risk factors mainly analyzed the impact of single pollutant exposure on health, while in fact, humans are constantly exposed to a complex mixture consisted of multiple pollutants/chemicals. In recent years, environmental epidemiologists have sought to assess adverse health effects of exposure to multi-pollutant mixtures based on the diversity of real-world environmental pollutants. However, the statistical challenges are considerable, for instance, multicollinearity and interaction among components of the mixture complicate the statistical analysis. There is currently no consensus on appropriate statistical methods. Here we summarized the practical statistical methods used in environmental epidemiology to estimate health effects of exposure to multi-pollutant mixture, such as Bayesian kernel machine regression (BKMR), weighted quantile sum (WQS) regressions, shrinkage methods (least absolute shrinkage and selection operator, elastic network model, adaptive elastic-net model, and principal component analysis), environment-wide association study (EWAS), etc. We sought to review these statistical methods and determine the application conditions, strengths, weaknesses, and result interpretability of each method, providing crucial insight and assistance for addressing epidemiological statistical issues regarding health effects from multi-pollutant mixture.","is_dataset_classified":null,"base_score":5.541263545158426,"endowment":5.541263545158426,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35487468","pmcid":null,"openalex_id":"https://openalex.org/W4224950666","authors":[],"funders":[],"total_grants":0,"fwci":20.6399,"citation_percentile":0.99788986,"influential_citations":0,"citation_trend":[{"year":2022,"count":10},{"year":2023,"count":50},{"year":2024,"count":73},{"year":2025,"count":73},{"year":2026,"count":48}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S026974912200570X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S026974912200570X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.envpol.2022.119356","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35487468","host_type":"repository"}],"fields_of_study":["Air Quality and Health Impacts","Health, Environment, Cognitive Aging","Nutritional Studies and Diet","Bayes Theorem","Environmental Exposure","Environmental Health","Environmental Pollutants","Epidemiologic Studies","Humans"],"mesh_terms":["Bayes Theorem","Environmental Exposure","Environmental Health","Environmental Pollutants","Humans","Epidemiologic Studies"],"keywords":["Pollutant","Environmental epidemiology","Multicollinearity","Interpretability","Environmental health","Statistical model","Statistics","Econometrics","Environmental pollution","Environmental science","Computer science","Risk analysis (engineering)","Regression analysis","Mathematics","Machine learning","Medicine","Environmental protection","Biology","Ecology","Health Effect","Statistical method","Bayesian Kernel Machine Regression","Multi-pollutant Mixture"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T23:41:12.159803Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}