{"doi":"10.1016/j.envint.2026.110302","title":"Associations of PFAS and phthalate/DINCH metabolites with metabolic regulation in teenagers from the HBM4EU aligned studies","abstract":null,"journal":"Environment International","year":2026,"id":601284,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1541715,"name":"Bianca Cox","orcid":"0000-0001-9824-6276","position":1,"is_corresponding":false},{"id":1541716,"name":"Hamid Y. Hassen","orcid":null,"position":2,"is_corresponding":false},{"id":855700,"name":"Eva Govarts","orcid":"0000-0002-6075-4862","position":3,"is_corresponding":false},{"id":1541717,"name":"Nina Iszatt","orcid":"0000-0002-8977-156X","position":4,"is_corresponding":false},{"id":1541718,"name":"Alicia Olivas-Martínez","orcid":"0000-0001-5237-9815","position":5,"is_corresponding":false},{"id":1541719,"name":"Elly den Hond","orcid":null,"position":6,"is_corresponding":false},{"id":1541720,"name":"Veerle J. Verheyen","orcid":null,"position":7,"is_corresponding":false},{"id":474641,"name":"Ľubica Palkovičová","orcid":"0000-0003-0438-2619","position":8,"is_corresponding":false},{"id":1541721,"name":"Lubica Palkovicova Murinova","orcid":null,"position":9,"is_corresponding":false},{"id":1541722,"name":"Susana Pedraza-Díaz","orcid":"0000-0001-9401-6473","position":10,"is_corresponding":false},{"id":1541723,"name":"Marta Esteban-López","orcid":"0000-0002-4527-350X","position":11,"is_corresponding":false},{"id":237198,"name":"Line Småstuen Haug","orcid":"0000-0001-6746-6399","position":12,"is_corresponding":false},{"id":237202,"name":"Amrit Kaur Sakhi","orcid":"0000-0002-2918-323X","position":13,"is_corresponding":false},{"id":1541724,"name":"Tina Kosjek","orcid":null,"position":14,"is_corresponding":false},{"id":1541725,"name":"Žiga Tkalec","orcid":null,"position":15,"is_corresponding":false},{"id":642993,"name":"Mariana F. Fernández","orcid":"0000-0001-6417-8914","position":16,"is_corresponding":false},{"id":36024,"name":"Sylvie Remy","orcid":"0000-0003-0322-9620","position":17,"is_corresponding":false},{"id":1541714,"name":"Andrea Rodríguez-Carrillo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Associations of PFAS and phthalate/DINCH metabolites with metabolic regulation in teenagers from the HBM4EU aligned studies","abstract":"BACKGROUND: Exposure to per- and polyfluoroalkyl substances (PFAS) and phthalates is widespread during adolescence, a critical developmental period for metabolic regulation. AIM: To assess associations of serum PFAS and urinary phthalate/DINCH metabolites-individually and as mixtures-with a unified panel of metabolic biomarkers representing adipose-brain-liver cross-talk and oxidative stress in European teenagers. METHODOLOGY: Serum PFAS and urinary phthalate/DINCH metabolites were measured in 1033 European teenagers (12-17 years) from the Human Biomonitoring Initiative for Europe (HBM4EU) Aligned Studies. Metabolic biomarkers representing adipose (HDL, LDL, cholesterol, and triglycerides)-brain (leptin, adiponectin, and kisspeptin)-liver (glucose, insulin) cross-talk and oxidative stress (8-hydroxy-2'-deoxyguanosine, 8OHdG) were measured. The Body Mass Index z-score (zBMI) was calculated. Single pollutant models, multivariate MANOVA, quantile g-computation, and BKMR models were fit, including interaction terms with sex. RESULTS: Single pollutant models showed positive associations of PFAS and phthalate/DINCH metabolites with 8OHdG. PFAS were associated with higher leptin, HDL, LDL, and cholesterol, while some phthalate/DINCH metabolites were associated with lower kisspeptin, HDL, triglycerides, cholesterol, zBMI, and higher adiponectin. We observed weak but statistically significant associations between PFAS and phthalate/DINCH metabolites with the entire set of metabolic biomarkers in the MANOVA. The PFAS mixture was associated with higher kisspeptin, LDL, HDL, cholesterol, and 8OHdG. The phthalate/DINCH mixture was associated with lower HDL. CONCLUSIONS: Exposure to these contaminants may be related to dyslipidemia in teenagers. PFAS and phthalate/DINCH metabolites may exert opposite associations on metabolism, with the exception of increasing oxidative stress. Given the cross‑sectional design and potential residual confounding, longitudinal studies are warranted.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42150235","pmcid":null,"openalex_id":"https://openalex.org/W7160891186","authors":[],"funders":[{"funder_name":"Norges Forskningsråd","grant_id":"275903","title":null},{"funder_name":"Norges Forskningsråd","grant_id":"268465","title":null},{"funder_name":"Government of Spain Ministry of Agriculture Fishing and Food","grant_id":"SEG 1321/15","title":null},{"funder_name":"Horizon 2020 Framework Programme","grant_id":"733032","title":"European Human Biomonitoring Initiative"},{"funder_name":"European Commission","grant_id":"101057014","title":"Partnership for the Assessment of Risks from Chemicals"},{"funder_name":"Norwegian Institute of Public Health","grant_id":"","title":null},{"funder_name":"European Commission","grant_id":"","title":null},{"funder_name":"Ministerio de Agricultura y Pesca, Alimentación y Medio Ambiente","grant_id":"","title":null},{"funder_name":"Carlos III Health Institute","grant_id":"","title":null},{"funder_name":"Horizon Europe","grant_id":"","title":null},{"funder_name":"European Health and Digital Executive Agency","grant_id":"","title":null}],"total_grants":11,"fwci":0.0,"citation_percentile":0.52145229,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1016/j.envint.2026.110302","host_type":"journal"},{"url":"https://doi.org/10.1016/j.envint.2026.110302","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0160412026002606?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0160412026002606?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42150235","host_type":"repository"},{"url":"https://www.sciencedirect.com/science/article/pii/S0160412026002606","host_type":"repository"},{"url":"https://dirros.openscience.si/IzpisGradiva.php?id=30185","host_type":"repository"},{"url":"https://doaj.org/article/8f8a935343864dd8afe33815fecc27e3","host_type":"repository"}],"fields_of_study":["Effects and risks of endocrine disrupting chemicals","Biochemical Acid Research Studies","Folate and B Vitamins Research"],"mesh_terms":["Biological Monitoring","Adolescent","Child","Environmental Exposure","Environmental Pollutants","Europe","Female","Fluorocarbons","Humans","Male","Phthalic Acids","Biomarkers","Oxidative Stress","Leptin","Adiponectin"],"keywords":["Metabolic regulation","Metabolite","Metabolic syndrome","Metabolic pathway","Metabolomics","Metabolism","Phthalates","Kisspeptin","Pfas","Hbm4eu","Effect Biomarkers"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T15:44:23.184836Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}