{"doi":"10.1016/j.envint.2025.109600","title":"A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects","abstract":"BACKGROUND: Residential buildings with a co-located dry-cleaning facility (CL-DC) can have substantially higher indoor tetrachloroethylene concentrations than buildings without a CL-DC. We conducted a case-control study to investigate associations between early-life indoor tetrachloroethylene exposure from CL-DCs and risks of childhood cancers (overall, acute lymphoblastic leukemia) and birth defects. METHODS: We linked records between the New York City (NYC) Bureau of Vital Statistics and the New York State Cancer Registry and Birth Defects Registry to identify cases of childhood cancers (n = 5,334) and birth defects (n = 171,553) diagnosed among children born in NYC between 1988 and 2016, and controls without these conditions (n = 596,599). We identified CL-DC exposure by mapping addresses from birth certificates and DC permits involving tetrachloroethylene use to building footprints, and modeled tetrachloroethylene concentrations using measurement data from a survey of NYC CL-DCs. Using unconditional logistic regression, we computed odds ratios (ORs) and 95 % confidence intervals (CIs) relating study endpoints to CL-DC exposure. FINDINGS: : OR = 3.9, 95 % CI = 1.6, 9.5) and stronger associations for children whose mother was non-White, less than college-educated, or lived at birth in majority non-White or poorer neighborhoods. We observed null findings for other endpoints. CONCLUSIONS: In this first-ever case-control study, early-life tetrachloroethylene exposure from CL-DCs in residential buildings was associated with increased AVS risk. These findings warrant further investigation.","journal":"Environment International","year":2025,"id":544698,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1435221,"name":"Adrian M Michalski","orcid":"0000-0002-3154-6466","position":1,"is_corresponding":false},{"id":436171,"name":"Margaret A. Gates","orcid":"0000-0002-2111-6227","position":2,"is_corresponding":false},{"id":1435617,"name":"Jamie Musco","orcid":null,"position":3,"is_corresponding":false},{"id":1435222,"name":"Catherine Adler","orcid":"0009-0008-5050-2961","position":4,"is_corresponding":false},{"id":951235,"name":"Shuai Xie","orcid":"0000-0002-0426-7613","position":5,"is_corresponding":false},{"id":417503,"name":"Melissa C. Friesen","orcid":"0000-0002-1695-3282","position":6,"is_corresponding":false},{"id":764526,"name":"Tabassum Z. Insaf","orcid":"0000-0003-4725-2515","position":7,"is_corresponding":false},{"id":241831,"name":"Mark P. Purdue","orcid":"0000-0003-1177-3108","position":8,"is_corresponding":false},{"id":733787,"name":"Jongeun Rhee","orcid":"0000-0003-1873-9359","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:53:17.418915Z","pmid":"40516285","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}